Sodium Salicylate Reduced Insulin Resistance in the Retina of a Type 2 Diabetic Rat Model - Jiang, Youde; Thakran, Shalini; Bheemreddy, Rajini; Coppess, William; Walker, Robert J.; Steinle, Jena J. (PloS one, 2015)
Keywords: Animal models; Animals; Apoptosis; Caspase; Caspase 3 - analysis; Caspase-3; Cells, Cultured; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetic retinopathy; Disease Models, Animal; Electroretinography; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Enzyme-Linked Immunosorbent Assay; Ependymoglial Cells - cytology; Ependymoglial Cells - drug effects; Ependymoglial Cells - metabolism; Glucose - pharmacology; Humans; I-kappa B Proteins - metabolism; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Receptor Substrate Proteins - metabolism; Insulin Resistance; Intraocular Pressure - physiology; Lysates; Male; Markers; NF-KappaB Inhibitor alpha; Nonsteroidal anti-inflammatory agents; Obesity; Phosphorylation - drug effects; Rats; Rats, Inbred BB; Receptor, Insulin - metabolism; Retina; Retina - drug effects; Retina - metabolism; Retinopathy; Salicylic acid; Signal Transduction - drug effects; Signaling; Sodium; Sodium salicylate; Sodium Salicylate - pharmacology; Substrates; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins - metabolism; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factor-α; Type 2 diabetes; Western blotting