Modulation of Protein Fermentation Does Not Affect Fecal Water Toxicity: A Randomized Cross-Over Study in Healthy Subjects

• Published in: PloS one Vol. 7; no. 12; p. e52387
• Main Authors: Windey, Karen, De Preter, Vicky, Louat, Thierry, Schuit, Frans, Herman, Jean, Vansant, Greet, Verbeke, Kristin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.12.2012; Public Library of Science (PLoS)
• Subjects: 1-Octanol; Acetic acid; Acids; Adult; Amines; Ammonia; Analysis; Benzene; Bioassay; Bioassays; Biology; Calorimetry; Cell Death - drug effects; Chemistry; Cluster Analysis; Colon; Colon - drug effects; Colon - metabolism; Comet assay; Correlation; Cresol; Cresols; Cross-Over Studies; Cytotoxicity; Damage detection; Diet; Dietary intake; Discriminant Analysis; Energy Intake - drug effects; Excretion; Feces - chemistry; Feces - microbiology; Female; Fermentation; Genotoxicity; Health; HT29 Cells; Humans; Indole; Indoles; Inhibitory Concentration 50; Isothiocyanate; Least-Squares Analysis; Male; Medicine; Metabolism; Metabolites; Metagenome; Microbiota; Microbiota (Symbiotic organisms); Mutagens - toxicity; Nutrition research; Octanoic acid; Octanol; Organic acids; p-Cresol; Parameter identification; Phenolic compounds; Phenols; Propionic acid; Proteins - metabolism; Rodents; Saturated fatty acids; Studies; Sulfur; Sulfur compounds; Toxicity; Water - chemistry; Water pollution; Water pollution effects; Young Adult; Belgium

Protein fermentation results in production of metabolites such as ammonia, amines and indolic, phenolic and sulfur-containing compounds. In vitro studies suggest that these metabolites might be toxic. However, human and animal studies do not consistently support these findings. We modified protein f...