Limited Utility of ITPA Deficiency to Predict Early Anemia in HCV Patients with Advanced Fibrosis Receiving Telaprevir

• Published in: PloS one Vol. 9; no. 4; p. e95881
• Main Authors: Aghemo, Alessio, Grassi, Eleonora, Rumi, Maria Grazia, D'Ambrosio, Roberta, Galmozzi, Enrico, Degasperi, Elisabetta, Castaldi, Davide, Soffredini, Roberta, Colombo, Massimo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Adenosine triphosphate; Adult; Aged; Anemia; Anemia - diagnosis; Anemia - etiology; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Antiviral drugs; Biology and Life Sciences; Blood; Blood transfusion; Cirrhosis; Development and progression; Drug therapy; Drug Therapy, Combination - adverse effects; Early Diagnosis; Erythropoietin; Female; Fibrosis; Gastroenterology; Genetic aspects; Genetic diversity; Genetic variance; Genetic Variation; Hemoglobin; Hepatitis; Hepatitis C; Hepatitis C - drug therapy; Hepatitis C - genetics; Hepatitis C - pathology; Hepatology; Humans; Infections; Interferon; Liver cirrhosis; Liver diseases; Male; Medicine and health sciences; Middle Aged; Oligopeptides - administration & dosage; Oligopeptides - adverse effects; Patient outcomes; Patients; Polymorphism, Single Nucleotide; Pyrophosphatases - genetics; Pyrophosphatases - metabolism; Reduction; Retrospective Studies; Ribavirin; Ribavirin - administration & dosage; Risk factors; Single nucleotide polymorphisms; Therapy; Transfusion; Triphosphatase; Viruses; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0095881

Severe anemia is a common side effect of Pegylated Interferon + Ribavirin (PR) and Telaprevir (TVR) in hepatitis C virus (HCV) genotype 1 patients with advanced fibrosis or cirrhosis (F3-F4). Inosine triphosphatase (ITPA) genetic variants are associated with RBV- induced anemia and dose reduction. T...