Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins

• Published in: PloS one Vol. 10; no. 3; p. e0120550
• Main Authors: Li, Li, Li, Xiang, The, Erlinda, Wang, Li-Jie, Yuan, Tian-You, Wang, Shi-Yi, Feng, Jing, Wang, Jing, Liu, Yuan, Wu, Ya-Han, Ma, Xiu-E, Ge, Jin, Cui, Ying-Yu, Jiang, Xiao-Yan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.03.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Annexin A2 - chemistry; Annexin A2 - metabolism; Annexins; Apoptosis; Breast cancer; Calcium ions; Calcium-binding protein; Cardiac arrhythmia; Cardiology; Cell cycle; Cell growth; Cell migration; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cyclin-Dependent Kinase Inhibitor p27 - genetics; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Education; Extracellular matrix; Female; Hospitals; Humans; Kinases; Laboratories; Male; Medicine; Middle Aged; Muscles; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - metabolism; Pathogenesis; Pathology; Protein Binding; Proteins; Ribonucleic acid; RNA; RNA Interference; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Small Interfering - metabolism; RNA-binding protein; Saphenous Vein - cytology; Smooth muscle; Transcription; Ultrasonic imaging; Veins; China

The cellular mechanisms of primary varicose great saphenous veins (GSVs) involve inflammation, apoptosis, and proliferation of local cells and extracellular matrix degradation. Long non-coding RNAs (lncRNAs) play important roles in these cellular processes; however, which and how lncRNAs related to...