Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury

• Published in: PloS one Vol. 7; no. 7; p. e40602
• Main Authors: Loiselle, Alayna E, Frisch, Benjamin J, Wolenski, Matthew, Jacobson, Justin A, Calvi, Laura M, Schwarz, Edward M, Awad, Hani A, O'Keefe, Regis J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2012; Public Library of Science (PLoS)
• Subjects: Adhesion; Animals; Biology; Biomechanics; Bone marrow; Bone Marrow Cells - enzymology; Bone marrow transplantation; Bone matrix; Cell migration; Cell Movement - physiology; Clonal deletion; Collagen; Collagen (type I); Collagen (type III); Dentistry; Female; Fibroblasts; Fibrosis; Gelatinase B; Gene expression; Gene Expression Regulation; Genes; Genetic engineering; Growth differentiation factor 5; Healing; Inflammation; Injuries; Injury prevention; Matrix metalloproteinase; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Medicine; Metalloproteinase; Mice; Mice, Knockout; Nervous system; Nonsteroidal anti-inflammatory drugs; Pathogenesis; Repair; Scars; Skin & tissue grafts; Stem cell transplantation; Stem cells; Tendon Injuries - enzymology; Tendon Injuries - pathology; Tendons; Tensile Strength; Tissue Adhesions; Wound Healing - genetics; New York; United States > US

The pathogenesis of adhesions following primary tendon repair is poorly understood, but is thought to involve dysregulation of matrix metalloproteinases (Mmps). We have previously demonstrated that Mmp9 gene expression is increased during the inflammatory phase following murine flexor digitorum (FDL...