Consequences of a Human TRPA1 Genetic Variant on the Perception of Nociceptive and Olfactory Stimuli
TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. Olf...
Saved in:
| Published in | PloS one Vol. 9; no. 4; p. e95592 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.04.2014
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity.
Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2).
Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced.
The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. |
|---|---|
| AbstractList | BACKGROUND: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. METHODS: Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2). RESULTS: Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced. CONCLUSIONS: The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. Background TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. Methods Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2). Results Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced. Conclusions The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2). Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced. The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity.BACKGROUNDTRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity.Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2).METHODSOlfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA1 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of H2S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of CO2).Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced.RESULTSAmong the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1±1.5 versus 12.3±1.6 correct discriminations) and indicated a higher intensity of the H2S stimuli (29.2±13.2 versus 21±12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced.The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants.CONCLUSIONSThe findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. Background: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA7 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. Methods: Olfactory function and nociception was compared between carriers (n = 38) and non-carriers (n = 43) of TRPA7 variant rs11988795 G>A, a variant known to enhance cold pain perception. Olfactory function was quantified by assessing the odor threshold, odor discrimination and odor identification, and by applying 200-ms pulses of [H.sub.2]S intranasal. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (blunt pressure, electrical stimuli, cold and heat stimuli, and 200-ms intranasal pulses of C[O.sub.2]). Results: Among the 11 subjects with moderate hyposmia, carriers of the minor A allele (n = 2) were underrepresented (34 carriers among the 70 normosmic subjects; p = 0.049). Moreover, carriers of the A allele discriminated odors significantly better than non-carriers (13.1 [+ or -] 1.5 versus 12.3 [+ or -] 1.6 correct discriminations) and indicated a higher intensity of the [H.sub.2]S stimuli (29.2 [+ or -] 13.2 versus 21 [+ or -] 12.8 mm VAS, p = 0.006), which, however, could not be excluded to have involved a trigeminal component during stimulation. Finally, the increased sensitivity to thermal pain could be reproduced. Conclusions: The findings are in line with a previous association of a human TRPA1 variant with nociceptive parameters and extend the association to the perception of odorants. However, this addresses mainly those stimulants that involve a trigeminal component whereas a pure olfactory effect may remain disputable. Nevertheless, findings suggest that future TRPA1 modulating drugs may modify the perception of odorants. |
| Audience | Academic |
| Author | Geisslinger, Gerd Schütz, Michael Walter, Carmen Lötsch, Jörn Oertel, Bruno G. Dimova, Violeta Doehring, Alexandra Heimann, Dirk |
| AuthorAffiliation | Duke University, United States of America 2 Fraunhofer Institute of Molecular Biology and Applied Ecology - Project Group Translational Medcine and Pharmacology (IME-TMP), Frankfurt am Main, Germany 1 Institute of Clinical Pharmacology, Goethe - University, Frankfurt am Main, Germany |
| AuthorAffiliation_xml | – name: Duke University, United States of America – name: 1 Institute of Clinical Pharmacology, Goethe - University, Frankfurt am Main, Germany – name: 2 Fraunhofer Institute of Molecular Biology and Applied Ecology - Project Group Translational Medcine and Pharmacology (IME-TMP), Frankfurt am Main, Germany |
| Author_xml | – sequence: 1 givenname: Michael surname: Schütz fullname: Schütz, Michael – sequence: 2 givenname: Bruno G. surname: Oertel fullname: Oertel, Bruno G. – sequence: 3 givenname: Dirk surname: Heimann fullname: Heimann, Dirk – sequence: 4 givenname: Alexandra surname: Doehring fullname: Doehring, Alexandra – sequence: 5 givenname: Carmen surname: Walter fullname: Walter, Carmen – sequence: 6 givenname: Violeta surname: Dimova fullname: Dimova, Violeta – sequence: 7 givenname: Gerd surname: Geisslinger fullname: Geisslinger, Gerd – sequence: 8 givenname: Jörn surname: Lötsch fullname: Lötsch, Jörn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24752136$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11r2zAUhs3oWD-2fzA2w2BsF8kk27KlXQxC2NpAWUrb9VYcS3KiYkuZJZf1309O3BKXMoYvbB0_73uko3OOowNjjYqitxhNcVrgL7e2aw3U000ITxFihLDkRXSEWZpM8gSlB3vfh9Gxc7cIkZTm-avoMMkKkuA0P4rk3BqnfnfKCOViW8UQn3UNmPj68mKG41NllNcivoFWg_GxNbFfq_hCtUJtvA7LIPlphd4u71QMRsbLugLhbXsfX3nddLV-Hb2soHbqzfA-iX79-H49P5ucL08X89n5ROQs8RNalBmtcimJyBjKsSSMpCojpSolLnDKcMkEIwqUTDKKUCUBykJCQRgVlOH0JHq_893U1vGhQI5jgiliBcqLQCx2hLRwyzetbqC95xY03wZsu-LQhgPXiqcJwkmGUwoIMplKRmkJeQIUYSjyjASvb0O2rmyUFMr4FuqR6fiP0Wu-snc8214ECwafBoPWhhtwnjfaCVXXYJTtdvvOkyRD_b4_PEGfP91ArSAcQJvKhryiN-WztCCEZgyjQE2focIjVaNF6KZKh_hI8HkkCIxXf_wKOuf44ury_9nlzZj9uMeuFdR-7Wzd9X3lxuC7_Uo_lvihjQOQ7QDRWudaVT0iGPF-Wh7Kxftp4cO0BNnXJzKhPfTpQ0V0_W_xX3hNGOs |
| CitedBy_id | crossref_primary_10_1016_j_ynstr_2021_100391 crossref_primary_10_3390_ijms232415989 crossref_primary_10_1177_0960327119877460 crossref_primary_10_7717_peerj_643 crossref_primary_10_1097_AJP_0000000000000677 crossref_primary_10_3390_ijms22073360 crossref_primary_10_1002_ejp_803 crossref_primary_10_1097_j_pain_0000000000001222 crossref_primary_10_4137_III_S25147 crossref_primary_10_4155_ppa_14_60 crossref_primary_10_1111_cts_12605 crossref_primary_10_3389_fphar_2018_01008 crossref_primary_10_1097_j_pain_0000000000000599 crossref_primary_10_3390_cimb47030204 crossref_primary_10_1016_j_drudis_2018_06_020 crossref_primary_10_1002_ejp_1173 crossref_primary_10_1016_j_neubiorev_2023_105227 crossref_primary_10_1111_bcpt_12485 |
| Cites_doi | 10.1038/nrd2757 10.1016/j.neuron.2010.04.030 10.1016/j.brainres.2003.12.011 10.1016/0304-3959(85)90175-7 10.1016/S1474-4422(10)70143-5 10.1007/s00424-011-1069-4 10.1080/13803391003683070 10.1007/s00429-013-0618-3 10.1016/j.jbi.2013.07.010 10.1073/pnas.1114124108 10.1186/1744-8069-3-6 10.1073/pnas.0705924104 10.1093/bioinformatics/bth457 10.1016/j.pain.2004.02.027 10.1007/s12078-010-9081-1 10.1371/journal.pone.0068654 10.1016/j.pain.2005.04.016 10.1136/jmg.2005.036079 10.1080/000164800750001134 10.1016/j.tips.2012.01.004 10.1016/j.pain.2007.12.015 10.1016/S0092-8674(03)00158-2 10.1371/journal.pone.0017387 10.1177/001316446002000104 10.1002/cne.903340110 10.1007/s00405-006-0173-0 10.1016/0031-9384(78)90070-7 10.1038/35077544 10.1068/p7244 10.1016/j.cell.2006.02.023 10.1093/chemse/22.1.39 10.1038/nature02168 10.1074/jbc.M110.106153 10.1038/nature02282 10.1016/j.neulet.2012.07.013 10.1523/JNEUROSCI.2992-10.2011 10.1016/j.jprot.2012.05.011 10.1136/jmedgenet-2011-100386 10.1126/science.1069424 10.1097/YPG.0b013e32832d0941 10.1371/journal.pone.0017724 10.1093/chemse/bjg054 10.1186/1744-8069-1-16 10.1007/s00420-002-0315-7 10.1038/423822a 10.1038/39807 10.1016/S0304-3959(99)00007-X 10.1038/nm1490 10.1016/j.pain.2009.06.001 10.1002/cne.10143 10.1016/S0167-8760(02)00150-2 10.1097/00005537-199807000-00015 10.3109/00016489.2010.489573 10.1038/clpt.2008.103 10.1038/265687a0 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 Public Library of Science 2014 Schütz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Schütz et al 2014 Schütz et al |
| Copyright_xml | – notice: COPYRIGHT 2014 Public Library of Science – notice: 2014 Schütz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Schütz et al 2014 Schütz et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0095592 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context Opposing Viewpoints Gale In Context Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Ecology |
| DocumentTitleAlternate | TRPA1 Genetics in Nociception and Olfaction |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1518097067 oai_doaj_org_article_320124138a0a4d3d988ba62a801a7645 PMC4005389 3281421701 A375584910 24752136 10_1371_journal_pone_0095592 |
| Genre | Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM BBORY CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS PUEGO RC3 7X8 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-87b48f6dd5c49061d5953e45bebd171391b9c95eaed24800fdaab7da7598c8913 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:14:25 EST 2021 Wed Aug 27 01:27:29 EDT 2025 Thu Aug 21 18:23:04 EDT 2025 Mon Jul 21 11:14:02 EDT 2025 Sat Aug 23 14:12:08 EDT 2025 Tue Jun 17 21:12:18 EDT 2025 Tue Jun 10 20:50:18 EDT 2025 Fri Jun 27 04:21:03 EDT 2025 Fri Jun 27 04:22:28 EDT 2025 Thu May 22 21:19:17 EDT 2025 Thu Apr 03 07:07:35 EDT 2025 Thu Apr 24 23:05:35 EDT 2025 Tue Jul 01 04:18:36 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-87b48f6dd5c49061d5953e45bebd171391b9c95eaed24800fdaab7da7598c8913 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: JL GG BGO. Performed the experiments: MS DH BGO CW VD AD. Analyzed the data: JL. Wrote the paper: JL BGO. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0095592 |
| PMID | 24752136 |
| PQID | 1518097067 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1518097067 doaj_primary_oai_doaj_org_article_320124138a0a4d3d988ba62a801a7645 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4005389 proquest_miscellaneous_1518622407 proquest_journals_1518097067 gale_infotracmisc_A375584910 gale_infotracacademiconefile_A375584910 gale_incontextgauss_ISR_A375584910 gale_incontextgauss_IOV_A375584910 gale_healthsolutions_A375584910 pubmed_primary_24752136 crossref_primary_10_1371_journal_pone_0095592 crossref_citationtrail_10_1371_journal_pone_0095592 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20140401 |
| PublicationDateYYYYMMDD | 2014-04-01 |
| PublicationDate_xml | – month: 04 year: 2014 text: 20140401 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | ref56 A Doehring (ref16) 2009; 19 CR McNamara (ref3) 2007; 104 JF Cordero-Morales (ref6) 2011; 108 PM Richards (ref11) 2010; 3 T Hummel (ref14) 2007; 264 BA Hastie (ref27) 2005; 116 T Komatsu (ref32) 2012; 463 ML Schaefer (ref35) 2002; 444 SE Jordt (ref10) 2004; 427 C International HapMap (ref60) 2003; 426 HW Dong (ref9) 2012; 524 KW Ho (ref57) 2012; 1 R Baron (ref29) 2010; 9 J Cohen (ref31) 1960; 20 ref50 S Malin (ref55) 2011; 31 G Kobal (ref40) 1998; 108 I Tegeder (ref46) 2006; 12 DM Bautista (ref59) 2006; 124 Y Nakashimo (ref8) 2010; 130 MJ Caterina (ref54) 1997; 389 T Hummel (ref18) 1997; 22 J Lötsch (ref44) 2013; 46 T Hummel (ref24) 2003; 47 ref43 TJ Neddermeyer (ref15) 2008; 138 A Doehring (ref49) 2011; 6 J Lötsch (ref48) 2009; 85 G Kobal (ref26) 1985; 22 R Baron (ref45) 2009; 146 B Kremeyer (ref2) 2010; 66 JC Barrett (ref63) 2005; 21 RL Doty (ref41) 1978; 20 ref34 SB Gabriel (ref62) 2002; 296 EE Young (ref1) 2012; 49 A Binder (ref28) 2011; 6 M Nolano (ref52) 1999; 81 M Wolfensberger (ref19) 2000; 120 J Lötsch (ref61) 2012; 33 AS Tarun (ref23) 2003; 28 GM Story (ref4) 2003; 112 A Staruschenko (ref58) 2010; 285 DD McKemy (ref51) 2005; 1 V Viswanath (ref5) 2003; 423 A Patapoutian (ref7) 2009; 8 H Kim (ref30) 2004; 109 D Heimann (ref13) 2013; 8 H Kim (ref12) 2006; 43 ref25 ref20 ref22 J Havlicek (ref39) 2012; 41 ref21 J Fernandez-Irigoyen (ref33) 2012; 75 L Jacquot (ref42) 2004; 1002 H Kim (ref47) 2007; 3 T Hummel (ref37) 2002; 75 DE Clapham (ref53) 2001; 2 M Hedner (ref38) 2010; 32 TE Finger (ref36) 1993; 334 F Sanger (ref17) 1977; 265 19512960 - Psychiatr Genet. 2009 Oct;19(5):259-68 23874707 - PLoS One. 2013;8(7):e68654 14578124 - Chem Senses. 2003 Sep;28(7):621-9 14685227 - Nature. 2003 Dec 18;426(6968):789-96 17057711 - Nat Med. 2006 Nov;12(11):1269-77 17686976 - Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30 14712238 - Nature. 2004 Jan 15;427(6971):260-5 22737633 - Am J Neurodegener Dis. 2012;1(1):1-14 23469704 - Perception. 2012;41(10):1246-61 11981669 - Int Arch Occup Environ Health. 2002 Jun;75(5):305-13 12654248 - Cell. 2003 Mar 21;112(6):819-29 15157710 - Pain. 2004 Jun;109(3):488-96 23928746 - Brain Struct Funct. 2014 Nov;219(6):1991-2000 22361590 - Trends Pharmacol Sci. 2012 Apr;33(4):193-9 12029063 - Science. 2002 Jun 21;296(5576):2225-9 17343757 - Mol Pain. 2007;3:6 662939 - Physiol Behav. 1978 Feb;20(2):175-85 12815418 - Nature. 2003 Jun 19;423(6942):822-3 11389472 - Nat Rev Neurosci. 2001 Jun;2(6):387-96 20231274 - J Biol Chem. 2010 May 14;285(20):15167-77 22222967 - Pflugers Arch. 2012 Apr;463(4):549-59 10353501 - Pain. 1999 May;81(1-2):135-45 870828 - Nature. 1977 Feb 24;265(5596):687-95 22058430 - J Med Genet. 2012 Jan;49(1):1-9 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 11603794 - Acta Otolaryngol. 2000 Mar;120(2):303-6 22609191 - J Proteomics. 2012 Jul 16;75(13):4005-16 20437286 - J Clin Exp Neuropsychol. 2010 Dec;32(10):1062-7 15964682 - Pain. 2005 Aug;116(3):227-37 14988033 - Brain Res. 2004 Mar 26;1002(1-2):51-4 16564016 - Cell. 2006 Mar 24;124(6):1269-82 21423693 - PLoS One. 2011;6(3):e17724 18243556 - Pain. 2008 Aug 31;138(2):286-91 9056084 - Chem Senses. 1997 Feb;22(1):39-52 9665252 - Laryngoscope. 1998 Jul;108(7):1033-5 19116627 - Nat Rev Drug Discov. 2009 Jan;8(1):55-68 12568945 - Int J Psychophysiol. 2003 Feb;47(2):147-58 20547126 - Neuron. 2010 Jun 10;66(5):671-80 11840476 - J Comp Neurol. 2002 Mar 12;444(3):221-6 20586674 - Acta Otolaryngol. 2010 Nov;130(11):1278-86 16882734 - J Med Genet. 2006 Aug;43(8):e40 21468319 - PLoS One. 2011;6(3):e17387 22820212 - Neurosci Lett. 2012 Aug 22;524(1):49-54 4047701 - Pain. 1985 Jun;22(2):151-63 7691899 - J Comp Neurol. 1993 Aug 1;334(1):117-24 21775597 - J Neurosci. 2011 Jul 20;31(29):10516-28 19592166 - Pain. 2009 Nov;146(1-2):34-40 20650402 - Lancet Neurol. 2010 Aug;9(8):807-19 23896390 - J Biomed Inform. 2013 Oct;46(5):921-8 18548001 - Clin Pharmacol Ther. 2009 Jan;85(1):25-30 9349813 - Nature. 1997 Oct 23;389(6653):816-24 21930928 - Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1184-91 15847696 - Mol Pain. 2005;1:16 17021776 - Eur Arch Otorhinolaryngol. 2007 Mar;264(3):237-43 |
| References_xml | – volume: 8 start-page: 55 year: 2009 ident: ref7 article-title: Transient receptor potential channels: targeting pain at the source publication-title: Nat Rev Drug Discov doi: 10.1038/nrd2757 – volume: 66 start-page: 671 year: 2010 ident: ref2 article-title: A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome publication-title: Neuron doi: 10.1016/j.neuron.2010.04.030 – ident: ref20 – volume: 1002 start-page: 51 year: 2004 ident: ref42 article-title: Unconscious odor detection could not be due to odor itself publication-title: Brain Res doi: 10.1016/j.brainres.2003.12.011 – volume: 22 start-page: 151 year: 1985 ident: ref26 article-title: Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation publication-title: Pain doi: 10.1016/0304-3959(85)90175-7 – volume: 9 start-page: 807 year: 2010 ident: ref29 article-title: Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment publication-title: Lancet Neurol doi: 10.1016/S1474-4422(10)70143-5 – volume: 463 start-page: 549 year: 2012 ident: ref32 article-title: Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner publication-title: Pflugers Arch doi: 10.1007/s00424-011-1069-4 – volume: 32 start-page: 1062 year: 2010 ident: ref38 article-title: Cognitive factors in odor detection, odor discrimination, and odor identification tasks publication-title: J Clin Exp Neuropsychol doi: 10.1080/13803391003683070 – ident: ref34 doi: 10.1007/s00429-013-0618-3 – ident: ref50 doi: 10.1016/j.jbi.2013.07.010 – volume: 1 start-page: 1 year: 2012 ident: ref57 article-title: TRPV1: a stress response protein in the central nervous system publication-title: Am J Neurodegener Dis – volume: 108 start-page: E1184 year: 2011 ident: ref6 article-title: Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1114124108 – volume: 3 start-page: 6 year: 2007 ident: ref47 article-title: Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans publication-title: Mol Pain doi: 10.1186/1744-8069-3-6 – volume: 104 start-page: 13525 year: 2007 ident: ref3 article-title: TRPA1 mediates formalin-induced pain publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0705924104 – volume: 21 start-page: 263 year: 2005 ident: ref63 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 109 start-page: 488 year: 2004 ident: ref30 article-title: Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament publication-title: Pain doi: 10.1016/j.pain.2004.02.027 – volume: 3 start-page: 190 year: 2010 ident: ref11 article-title: For irritating odorants target the trigeminal chemoreceptor TRPA1 publication-title: Chem Percept doi: 10.1007/s12078-010-9081-1 – volume: 8 start-page: e68654 year: 2013 ident: ref13 article-title: Linkage between Increased Nociception and Olfaction via a SCN9A Haplotype publication-title: PLoS One doi: 10.1371/journal.pone.0068654 – volume: 116 start-page: 227 year: 2005 ident: ref27 article-title: Cluster analysis of multiple experimental pain modalities publication-title: Pain doi: 10.1016/j.pain.2005.04.016 – volume: 43 start-page: e40 year: 2006 ident: ref12 article-title: Genetic predictors for acute experimental cold and heat pain sensitivity in humans publication-title: J Med Genet doi: 10.1136/jmg.2005.036079 – volume: 120 start-page: 303 year: 2000 ident: ref19 article-title: Sniffin’Sticks: a new olfactory test battery publication-title: Acta Otolaryngol doi: 10.1080/000164800750001134 – volume: 33 start-page: 193 year: 2012 ident: ref61 article-title: Sniffing out pharmacology: interactions of drugs with human olfaction publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2012.01.004 – volume: 138 start-page: 286 year: 2008 ident: ref15 article-title: Principal components analysis of pain thresholds to thermal, electrical, and mechanical stimuli suggests a predominant common source of variance publication-title: Pain doi: 10.1016/j.pain.2007.12.015 – volume: 112 start-page: 819 year: 2003 ident: ref4 article-title: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures publication-title: Cell doi: 10.1016/S0092-8674(03)00158-2 – volume: 6 start-page: e17387 year: 2011 ident: ref28 article-title: Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients publication-title: PloS one doi: 10.1371/journal.pone.0017387 – volume: 20 start-page: 37 year: 1960 ident: ref31 article-title: A coefficient of agreement for nominal scale publication-title: J Educat Psychol Measure doi: 10.1177/001316446002000104 – volume: 334 start-page: 117 year: 1993 ident: ref36 article-title: Peripheral peptidergic fibers of the trigeminal nerve in the olfactory bulb of the rat publication-title: J Comp Neurol doi: 10.1002/cne.903340110 – volume: 264 start-page: 237 year: 2007 ident: ref14 article-title: Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects publication-title: Eur Arch Otorhinolaryngol doi: 10.1007/s00405-006-0173-0 – volume: 20 start-page: 175 year: 1978 ident: ref41 article-title: Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans publication-title: Physiol Behav doi: 10.1016/0031-9384(78)90070-7 – volume: 2 start-page: 387 year: 2001 ident: ref53 article-title: The TRP ion channel family publication-title: Nat Rev Neurosci doi: 10.1038/35077544 – volume: 41 start-page: 1246 year: 2012 ident: ref39 article-title: Olfactory perception is positively linked to anxiety in young adults publication-title: Perception doi: 10.1068/p7244 – volume: 124 start-page: 1269 year: 2006 ident: ref59 article-title: TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents publication-title: Cell doi: 10.1016/j.cell.2006.02.023 – volume: 22 start-page: 39 year: 1997 ident: ref18 article-title: “Sniffin’ Sticks”: Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold publication-title: Chem Senses doi: 10.1093/chemse/22.1.39 – ident: ref22 – ident: ref25 – volume: 426 start-page: 789 year: 2003 ident: ref60 article-title: The International HapMap Project publication-title: Nature doi: 10.1038/nature02168 – ident: ref43 doi: 10.1007/s00429-013-0618-3 – volume: 285 start-page: 15167 year: 2010 ident: ref58 article-title: Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel publication-title: J Biol Chem doi: 10.1074/jbc.M110.106153 – volume: 427 start-page: 260 year: 2004 ident: ref10 article-title: Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 publication-title: Nature doi: 10.1038/nature02282 – volume: 524 start-page: 49 year: 2012 ident: ref9 article-title: Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb publication-title: Neurosci Lett doi: 10.1016/j.neulet.2012.07.013 – volume: 31 start-page: 10516 year: 2011 ident: ref55 article-title: TRPV1 and TRPA1 function and modulation are target tissue dependent publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2992-10.2011 – volume: 75 start-page: 4005 year: 2012 ident: ref33 article-title: Proteomic atlas of the human olfactory bulb publication-title: J Proteomics doi: 10.1016/j.jprot.2012.05.011 – volume: 46 start-page: 921 year: 2013 ident: ref44 article-title: A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain publication-title: J Biomed Inform doi: 10.1016/j.jbi.2013.07.010 – volume: 49 start-page: 1 year: 2012 ident: ref1 article-title: Genetic basis of pain variability: recent advances publication-title: J Med Genet doi: 10.1136/jmedgenet-2011-100386 – volume: 296 start-page: 2225 year: 2002 ident: ref62 article-title: The structure of haplotype blocks in the human genome publication-title: Science doi: 10.1126/science.1069424 – volume: 19 start-page: 259 year: 2009 ident: ref16 article-title: Genetic diagnostics of functional variants of the human dopamine D2 receptor gene publication-title: Psychiatr Genet doi: 10.1097/YPG.0b013e32832d0941 – volume: 6 start-page: e17724 year: 2011 ident: ref49 article-title: Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures publication-title: PloS one doi: 10.1371/journal.pone.0017724 – volume: 28 start-page: 621 year: 2003 ident: ref23 article-title: Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa publication-title: Chemical senses doi: 10.1093/chemse/bjg054 – volume: 1 start-page: 16 year: 2005 ident: ref51 article-title: How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation publication-title: Mol Pain doi: 10.1186/1744-8069-1-16 – volume: 75 start-page: 305 year: 2002 ident: ref37 article-title: Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfaction publication-title: Int Arch Occ Env Health doi: 10.1007/s00420-002-0315-7 – volume: 423 start-page: 822 year: 2003 ident: ref5 article-title: Opposite thermosensor in fruitfly and mouse publication-title: Nature doi: 10.1038/423822a – volume: 389 start-page: 816 year: 1997 ident: ref54 article-title: The capsaicin receptor: a heat-activated ion channel in the pain pathway publication-title: Nature doi: 10.1038/39807 – ident: ref21 – volume: 81 start-page: 135 year: 1999 ident: ref52 article-title: Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation publication-title: Pain doi: 10.1016/S0304-3959(99)00007-X – volume: 12 start-page: 1269 year: 2006 ident: ref46 article-title: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence publication-title: Nat Med doi: 10.1038/nm1490 – volume: 146 start-page: 34 year: 2009 ident: ref45 article-title: A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms publication-title: Pain doi: 10.1016/j.pain.2009.06.001 – volume: 444 start-page: 221 year: 2002 ident: ref35 article-title: Trigeminal collaterals in the nasal epithelium and olfactory bulb: a potential route for direct modulation of olfactory information by trigeminal stimuli publication-title: J Comp Neurol doi: 10.1002/cne.10143 – ident: ref56 – volume: 47 start-page: 147 year: 2003 ident: ref24 article-title: Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuli publication-title: Int J Psychophysiol doi: 10.1016/S0167-8760(02)00150-2 – volume: 108 start-page: 1033 year: 1998 ident: ref40 article-title: Olfactory and intranasal trigeminal event-related potentials in anosmic patients publication-title: Laryngoscope doi: 10.1097/00005537-199807000-00015 – volume: 130 start-page: 1278 year: 2010 ident: ref8 article-title: Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium publication-title: Acta Otolaryngol doi: 10.3109/00016489.2010.489573 – volume: 85 start-page: 25 year: 2009 ident: ref48 article-title: The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2008.103 – volume: 265 start-page: 687 year: 1977 ident: ref17 article-title: Nucleotide sequence of bacteriophage phi X174 DNA publication-title: Nature doi: 10.1038/265687a0 – reference: 9056084 - Chem Senses. 1997 Feb;22(1):39-52 – reference: 15157710 - Pain. 2004 Jun;109(3):488-96 – reference: 12568945 - Int J Psychophysiol. 2003 Feb;47(2):147-58 – reference: 12029063 - Science. 2002 Jun 21;296(5576):2225-9 – reference: 17021776 - Eur Arch Otorhinolaryngol. 2007 Mar;264(3):237-43 – reference: 10353501 - Pain. 1999 May;81(1-2):135-45 – reference: 14988033 - Brain Res. 2004 Mar 26;1002(1-2):51-4 – reference: 14712238 - Nature. 2004 Jan 15;427(6971):260-5 – reference: 17686976 - Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30 – reference: 21930928 - Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1184-91 – reference: 19512960 - Psychiatr Genet. 2009 Oct;19(5):259-68 – reference: 17057711 - Nat Med. 2006 Nov;12(11):1269-77 – reference: 17343757 - Mol Pain. 2007;3:6 – reference: 20586674 - Acta Otolaryngol. 2010 Nov;130(11):1278-86 – reference: 19116627 - Nat Rev Drug Discov. 2009 Jan;8(1):55-68 – reference: 662939 - Physiol Behav. 1978 Feb;20(2):175-85 – reference: 4047701 - Pain. 1985 Jun;22(2):151-63 – reference: 15847696 - Mol Pain. 2005;1:16 – reference: 23928746 - Brain Struct Funct. 2014 Nov;219(6):1991-2000 – reference: 20547126 - Neuron. 2010 Jun 10;66(5):671-80 – reference: 9665252 - Laryngoscope. 1998 Jul;108(7):1033-5 – reference: 14578124 - Chem Senses. 2003 Sep;28(7):621-9 – reference: 21423693 - PLoS One. 2011;6(3):e17724 – reference: 7691899 - J Comp Neurol. 1993 Aug 1;334(1):117-24 – reference: 22361590 - Trends Pharmacol Sci. 2012 Apr;33(4):193-9 – reference: 23874707 - PLoS One. 2013;8(7):e68654 – reference: 20437286 - J Clin Exp Neuropsychol. 2010 Dec;32(10):1062-7 – reference: 11981669 - Int Arch Occup Environ Health. 2002 Jun;75(5):305-13 – reference: 22222967 - Pflugers Arch. 2012 Apr;463(4):549-59 – reference: 21775597 - J Neurosci. 2011 Jul 20;31(29):10516-28 – reference: 12654248 - Cell. 2003 Mar 21;112(6):819-29 – reference: 22820212 - Neurosci Lett. 2012 Aug 22;524(1):49-54 – reference: 14685227 - Nature. 2003 Dec 18;426(6968):789-96 – reference: 16882734 - J Med Genet. 2006 Aug;43(8):e40 – reference: 11389472 - Nat Rev Neurosci. 2001 Jun;2(6):387-96 – reference: 20231274 - J Biol Chem. 2010 May 14;285(20):15167-77 – reference: 11603794 - Acta Otolaryngol. 2000 Mar;120(2):303-6 – reference: 9349813 - Nature. 1997 Oct 23;389(6653):816-24 – reference: 23896390 - J Biomed Inform. 2013 Oct;46(5):921-8 – reference: 15964682 - Pain. 2005 Aug;116(3):227-37 – reference: 21468319 - PLoS One. 2011;6(3):e17387 – reference: 18548001 - Clin Pharmacol Ther. 2009 Jan;85(1):25-30 – reference: 12815418 - Nature. 2003 Jun 19;423(6942):822-3 – reference: 20650402 - Lancet Neurol. 2010 Aug;9(8):807-19 – reference: 16564016 - Cell. 2006 Mar 24;124(6):1269-82 – reference: 22058430 - J Med Genet. 2012 Jan;49(1):1-9 – reference: 11840476 - J Comp Neurol. 2002 Mar 12;444(3):221-6 – reference: 23469704 - Perception. 2012;41(10):1246-61 – reference: 18243556 - Pain. 2008 Aug 31;138(2):286-91 – reference: 870828 - Nature. 1977 Feb 24;265(5596):687-95 – reference: 22609191 - J Proteomics. 2012 Jul 16;75(13):4005-16 – reference: 22737633 - Am J Neurodegener Dis. 2012;1(1):1-14 – reference: 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 – reference: 19592166 - Pain. 2009 Nov;146(1-2):34-40 |
| SSID | ssj0053866 |
| Score | 2.240371 |
| Snippet | TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with... Background: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA7 genetics... Background TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics... BACKGROUND: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics... Background TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e95592 |
| SubjectTerms | Adult Alleles Analysis Aroma compounds Biology and Life Sciences Calcium Channels - genetics Carbon dioxide Carriers Cold Cold pressing Deoxyribonucleic acid Diabetic neuropathy DNA Drugs Ecology Electrical stimuli Female Gene mutations Genetic diversity Genetic variance Genetic variation Genetics Genotype & phenotype Haplotypes Heat stimuli Humans Hydrogen sulfide Hypotheses Ion channels Male Medicine and Health Sciences Molecular biology Mutation Nerve Tissue Proteins - genetics Nociception Odor thresholds Odorants Odors Olfaction Olfaction disorders Olfactory discrimination Olfactory discrimination learning Olfactory stimuli Olfactory thresholds Pain Pain - genetics Pain perception Pain sensitivity Perception Pharmacology Phenotype Polymorphism, Single Nucleotide - genetics Semantics Sensitivity Sensory stimulation Smell - genetics Stimulants Temperature perception Transient Receptor Potential Channels - genetics TRPA1 Cation Channel White people Whites Young Adult |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBFgxCAg5p8_AjPi4VVUHiodKi3iwndgrSKlk1u5X498zY3miDKpUD2lPW42h3Xp7RjL8h5DWCPknLsxRLoynjRZ0qxk3qStXARzBrsKL7-Ys4OWefLvjF1qgv7AkL8MCBcYclnFBY-6lMZpgtraqq2ojCgGc1UjCPXgpn3iaZCj4YrFiIeFGulPlhlMvBsu_cQUBdKyYHkcfrH73ybLnoh5tCzr87J7eOouP75F6MIek8_PYdcsd1D8hOtNKBvo1Q0u8eEnu01SxN-5Ya6ofy0bPTb_OcgvLgHUZ6DQkzcJj2HYV4kC7HZhfc0oH4_OO1o6aztF-EGT2_KXgHbK56RM6PP5wdnaRxrkLaCFWswAHWrGqFtbxhCs5zyxUvHeO1q20OSavKaxATd8bZgkFA2VpjammN5KpqsKz5mMw64OQuoY2TWMvNGyEUMyKrizYzeV6D12isUjIh5YbJuomg4zj7YqF9JU1C8hF4plE0OoomIem4axlAN26hf4_yG2kRMtt_AYqkoyLp2xQpIS9Q-jrcPx0NX89LySFKg7AqIa88BcJmdNiXc2nWw6A_fv3xD0TfTydEbyJR2wM7GhPvQsB_QjiuCeXehBKMv5ks76KubrgyaAjgqkyhUGDnRn9vXn45LuNLsdeuc_060Aif6SfkSVD3kbMFkxDvlSIhcmIIE9ZPV7pfPz1qOfNmqZ7-D1k9I3eBInZQ7ZHZ6mrt9iE4XNXPvR_4A0OOX5Q priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegCIkXxMbHAgMMQgIesuXDH_ETKtOmgcQ27Ut9ixzbHZOqpCwt0v577hw3LGgC1KfW5yi9853vfOffEfIOQZ-k5UmMqdGY8ayKFeM6drky8BHMaszofjsQ-2fs64RPwoFbG8oqVzbRG2rbGDwj34adqUiUBOP6af4jxq5RmF0NLTTuknsIXYYlXXLSB1ygy0KE63K5TLeDdLbmTe22Ouy1bLAdedT-3jaP5rOmvc3x_LN-8saGtPeIPAyeJB13ol8jd1y9Tu7vehTq63WyFrS2pR8CtPTHx8Tu3Cieps2UaupP8enp8dE4pUgIT6PnEEADx2lTU_AP6VFf_IJTDkCc_utPR3Vt6eGs69lzTU8Wl1hs9YSc7e2e7uzHoc9CbITKFmAQK1ZMhbXcMAX7u-WK547xylU2hSBWpRWIjTvtbMbAwZxarStpteSqMJjmfEpGNfB0g1DjUEJZaoRQTIukyqaJTtMKrIixSsmI5Ct2lyaAkGMvjFnpM2sSgpGOeyUKqQxCikjcz5p3IBz_oP-MkuxpEULb_9BcXZRBI8scXB9MKhY60czmVhVFpUWmYcvWUjAekde4DsruPmpvCMpxLjl4beBmReStp0AYjRrrdC70sm3LL4fn_0F0cjwgeh-Ipg2ww-hwNwL-E8JzDSg3B5RgDMxgeANX7YorbflbbWDmaiXfPvymH8aHYu1d7ZplRyN85B-RZ93C7zmbMQn-Xy4iIgcqMWD9cKS-_O5RzJlXUPX876_1gjwAOYVaqU0yWlwt3UtwAxfVK6_rvwBHslq3 priority: 102 providerName: ProQuest |
| Title | Consequences of a Human TRPA1 Genetic Variant on the Perception of Nociceptive and Olfactory Stimuli |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24752136 https://www.proquest.com/docview/1518097067 https://www.proquest.com/docview/1518622407 https://pubmed.ncbi.nlm.nih.gov/PMC4005389 https://doaj.org/article/320124138a0a4d3d988ba62a801a7645 http://dx.doi.org/10.1371/journal.pone.0095592 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdG98ILYnwtMIpBSMBDqnw4dvyAUFetDKR1VbdOfYucOB2TqqQ0LWL_PXeOGy2oCFCkSKnPlnrnO__sO98R8haTPgkdeS66Rl0WBakrWaTcPJQZPJxphR7dsxE_nbKvs2i2R7Y1Wy0Dq51bO6wnNV0tej-_334Chf9oqjYIf9uptyyLvFfnVAOjvA9rk0BVPWONXwG023gvEbW4PPBCe5nuT6O0FiuT07-x3J3loqx2wdLfoyvvLFfDh-SBxZm0X0-MA7KXF4_IgdXkir636aY_PCZ6cCegmpZzqqg52aeXk3Hfp0gIY9Ar2FSDFGhZUMCMdNwExGCXEYjYfP7IqSo0PV_UdXxu6cX6BgOwnpDp8ORycOra2gtuxmWwBiOZsnjOtY4yJmHN15GMwpxFaZ5qYGso_RREGeUq1wED0DnXSqVCKxHJOEPX51PSKYCTh4RmuUB_r59xLpniXhrMPeX7KViWTEspHBJumZxkNjE51sdYJMbbJmCDUvMsQdEkVjQOcZteyzoxx1_oj1F-DS2m1TY_lKvrxGppEgIcQkdjrDzFdKhlHKeKBwqWcSU4ixzyCqWf1HdUG-OQ9EMRAZID6OWQN4YCU2sUGLtzrTZVlXw5v_oHootJi-idJZqXwI5M2fsS8J8wZVeL8qhFCQYiazUf4lzdcqVKAOTFnkShQM_t_N3d_LppxkExHq_Iy01Nw81pgEOe1dO94WzABGDCkDtEtBShxfp2S3HzzWQ2Z0ZF5fP_lO0Lch8EZwOqjkhnvdrkLwErrtMuuSdmAt7xwMf38HOX7B-fjMaTrjl96Rrz8AvS2Grg |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1db9Mw0BpFCF4QGx8LDGYQCPaQLR-OHT8gVMamlm3dtHVT34ITu2NSlZSlBfVP8Ru5yxcLmoCXqU-tz1Z635c73xHyGps-CR04NqZGbRZ4sS1ZoGzjywQ-nGmFGd2DAe-dss-jYLREftZ3YbCsstaJhaLWWYLvyLfAMoWOFKBcP0y_2Tg1CrOr9QiNki32zOIHhGz5-_4noO8bz9vdGW737GqqgJ1w6c1A_GMWjrnWQcIkWDMdyMA3LIhNrF0I2aQbw0MGRhntMXCnxlqpWGglAhkmmNSDc2-R22B4HZQoMWoCPNAdnFfX83zhblXcsDnNUrNZ9nrzWuavmBLQ2ILOdJLl1zm6f9ZrXjGAuw_I_cpzpd2S1ZbJkklXyJ2douv1YoUsV1oip--qVtYbD4nevlKsTbMxVbTIGtDh8VHXpQgIp9EzCNiBwjRLKfij9KgptsEtA2Cf4ut3Q1Wq6eGknBG0oCezCyzuekROb4QCj0knBZyuEpoY5AjPTTiXTHEn9saOct0YtFaipRQW8Wt0R0nV9Bxnb0yiIpMnIPgpsRchkaKKSBaxm13TsunHP-A_IiUbWGzZXfyQXZ5HlQaIfHC1MIkZKkcx7WsZhrHingIXQQnOAousIx9E5f3XRvFEXV8E4CWCW2eRVwUEtu1IsS7oXM3zPOofnv0H0MlxC-htBTTOAB2Jqu5iwH_CdmAtyLUWJCifpLW8ilxbYyWPfosp7Kw5-frll80yHoq1fqnJ5iUML940WORJyfgNZj0mwN_0uUVESyRaqG-vpBdfi67prBBQ-fTvj7VO7vaGB_vRfn-w94zcA5pVdVprpDO7nJvn4ILO4heF3FPy5aYVzS9_TJfw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VIBAXRMujhkIXBAIObmJ7H9kDQqFt1FBIo76Um1l77VIpskOTgPLX-HXM2GtTowq4VDklO7ty5vHtrGd2hpCXWPRJGt5xMTTqMu5HrmJcu0mgYvgIZjRGdD8Pxd4J-zjm4xXys7oLg2mVFSYWQG3yGN-Rt2Fn6naUBHBtpzYtYrTTfz_95mIHKYy0Vu00ShXZT5Y_4Pg2ezfYAVm_8v3-7vH2nms7DLixUP4coCBi3VQYw2OmYGczXPEgYTxKIuPB8U15ETwwT3RifAauVWq0jqTRkqtujAE-WPcGuSkD7qGNyXF92AMcEcJe1Quk17aasTXNs2SrrPvmN7bComNAvS-0ppN8dpXT-2fu5qXNsH-P3LVeLO2VardKVpJsjdzaLSpgL9fIqkWMGX1jy1q_vU_M9qXEbZqnVNMigkCPD0c9jyIhrEZP4fAO0qZ5RsE3paM68QanDEGViq_fE6ozQw8mZb-gJT2an2Oi1wNyci0SeEhaGfB0ndA4Qe3wvVgIxbToRH7a0Z4XAYLFRinpkKBidxjbAujYh2MSFlE9CQehknshCim0QnKIW8-algVA_kH_ASVZ02L57uKH_OIstGgQBuB2YUCzqzuamcCobjfSwtfgLmgpGHfIJupBWN6FrUEo7AWSg8cILp5DXhQUWMIjQ2M404vZLBwcnP4H0dFhg-i1JUpzYEes7b0M-E9YGqxBudGgBCCKG8PrqLUVV2bhb5OFmZUmXz38vB7GRTHvL0vyRUkjircODnlUKn7NWZ9J8D0D4RDZMIkG65sj2fnXooI6KwxUPf77Y22S2wAx4afBcP8JuQMisylbG6Q1v1gkT8EbnUfPCrOn5Mt148wvtwGcJg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Consequences+of+a+Human+TRPA1+Genetic+Variant+on+the+Perception+of+Nociceptive+and+Olfactory+Stimuli&rft.jtitle=PloS+one&rft.au=Sch%C3%BCtz%2C+Michael&rft.au=Oertel%2C+Bruno+G.&rft.au=Heimann%2C+Dirk&rft.au=Doehring%2C+Alexandra&rft.date=2014-04-01&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=9&rft.issue=4&rft.spage=e95592&rft_id=info:doi/10.1371%2Fjournal.pone.0095592&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0095592 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |