Aged blood factors decrease cellular responses associated with delayed gingival wound repair

• Published in: PloS one Vol. 12; no. 9; p. e0184189
• Main Authors: Saldías, María Paz, Fernández, Christian, Morgan, Alejandra, Díaz, Catalina, Morales, Diego, Jaña, Fabián, Gómez, Alvaro, Silva, Alonso, Briceño, Fernanda, Oyarzún, Alejandro, Maldonado, Felipe, Cerda, Oscar, Smith, Patricio C., Cáceres, Mónica
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2017; Public Library of Science (PLoS)
• Subjects: Actin; Age; Age Factors; Aged; Aged, 80 and over; Aging; Aging - blood; Analysis; Animals; beta-Galactosidase - metabolism; Biological activity; Biology; Biology and Life Sciences; Blood; Blood platelets; Cell adhesion & migration; Cell Cycle - drug effects; Cell Differentiation - drug effects; Cell Proliferation; Connective tissues; Cytokines; Cytokines - blood; Cytokines - pharmacology; Cytometry; Dentistry; Deoxyribonucleic acid; Diabetes; Differentiation; Disease Models, Animal; DNA; Extracellular matrix; Fibroblasts; Fibroblasts - metabolism; Flow cytometry; Galactosidase; Genetic aspects; Gingiva; Gingiva - drug effects; Gingiva - metabolism; Gingiva - pathology; Growth factors; Histone H2A; Humans; Immunofluorescence; In vitro methods and tests; Inflammation; Inflammation Mediators - blood; Inflammation Mediators - pharmacology; Interleukin 6; Male; Medicine; Medicine and Health Sciences; Middle Aged; Monocyte chemoattractant protein 1; Myofibroblasts - cytology; Myofibroblasts - drug effects; Myofibroblasts - metabolism; Physiological aspects; Platelet-derived growth factor; Rats; Repair; Senescence; Serum; Smooth muscle; Staining; Tissues; Tumor necrosis factor; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Wound healing; Wound Healing - drug effects; β-Galactosidase; Chile

Aging is a gradual biological process characterized by a decrease in cell and organism functions. Gingival wound healing is one of the impaired processes found in old rats. Here, we studied the in vivo wound healing process using a gingival repair rat model and an in vitro model using human gingival...