Effect of vitamin D on endothelial progenitor cells function

• Published in: PloS one Vol. 12; no. 5; p. e0178057
• Main Authors: Hammer, Yoav, Soudry, Alissa, Levi, Amos, Talmor-Barkan, Yeela, Leshem-Lev, Dorit, Singer, Joel, Kornowski, Ran, Lev, Eli I
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.05.2017; Public Library of Science (PLoS)
• Subjects: 25-Hydroxyvitamin D; Abnormalities; Acute coronary syndromes; Adult; Adults; Age; Aged; Alanine; Alanine transaminase; Anemia; Antigens; Arteriosclerosis; Atherosclerosis; Attenuation; Autocrine signalling; Biocompatibility; Biology and Life Sciences; Blood; Blood circulation; Bone marrow; Brain; Calcitriol; Calcitriol - pharmacology; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular system; CD34 antigen; Cell adhesion; Cell differentiation; Cell surface; Cell Survival - drug effects; Cells (biology); Centrifugation; Coronary artery; Coronary artery disease; Coronary vessels; Diabetes; Diabetes mellitus; Diabetes Mellitus - metabolism; Differentiation; Early Growth Response Transcription Factors - metabolism; Endocrinology; Endothelial Progenitor Cells - cytology; Endothelial Progenitor Cells - drug effects; Female; Genetics; Glycocalyx; Health aspects; Heart; Heart diseases; Hematology; Hemodialysis; Hemoglobin; Hospitals; Humans; Hypertension; Immune system; Inflammation; Insulin; Kidneys; Kruppel-Like Transcription Factors - metabolism; Lysis; Male; Medical research; Medical treatment; Medicine; Medicine and Health Sciences; Metabolism; Middle Aged; Mortality; Patients; Phosphates; Physical sciences; Rats; Research and analysis methods; Restoration; Risk factors; Smoking; Stroke; Studies; Vascular endothelial growth factor; Vitamin D; Vitamin D - pharmacology; Vitamin deficiency; Young Adult; Israel

Endothelial progenitor cells (EPCs) are a population of bone marrow-derived cells, which have an important role in the process of endothelialization and vascular repair following injury. Impairment of EPCs, which occurs in patients with diabetes, was shown to be related to endothelial dysfunction, c...