Importance of Reciprocal Balance of T Cell Immunity in Mycobacterium abscessus Complex Lung Disease

Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-asso...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 9; no. 10; p. e109941
Main Authors Kim, Su-Young, Koh, Won-Jung, Kim, Yee Hyung, Jeong, Byeong-Ho, Park, Hye Yun, Jeon, Kyeongman, Kim, Jong-Seok, Cho, Sang-Nae, Shin, Sung Jae
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.10.2014
Public Library of Science (PLoS)
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biological response modifiers
Biology and Life Sciences
Care and treatment
Chemokines
Comparative analysis
Conversion
Critical care
Cystic fibrosis
Cytokines
Cytokines - blood
Defects
Defense mechanisms
Drug resistance
Female
Health aspects
Helper cells
Humans
Immune response
Immune system
Immunity
Immunity (Disease)
Immunology
Infection
Infections
Interferon
Interleukin 13
Interleukin 17
Interleukin 23
Interleukin 4
IP-10 protein
Kim, Won
Lung diseases
Lung Diseases - blood
Lung Diseases - drug therapy
Lung Diseases - immunology
Lymphocytes T
Male
Medicine
Medicine and Health Sciences
Microbiology
Middle Aged
Mycobacterium
Mycobacterium Infections, Nontuberculous - blood
Mycobacterium Infections, Nontuberculous - drug therapy
Mycobacterium Infections, Nontuberculous - immunology
Mycobacterium tuberculosis
Nontuberculous Mycobacteria - physiology
Patients
Sputum
Studies
T cells
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Tuberculosis
Tumor necrosis factor-TNF
Viral infections
γ-Interferon
South Korea
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0109941

Cover

Abstract Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
AbstractList Background Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. Methods A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. Results In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γprotein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Conclusion Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics.A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system.In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion.Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
Background Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. Methods A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. Results In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γprotein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Conclusion Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-[gamma] and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-[gamma]-induced protein (IP)-10 and monokine induced by IFN-[gamma]protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-[gamma], may serve as key markers for indicating the treatment outcome.
Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics.BACKGROUNDLittle is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics.A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system.METHODSA total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system.In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion.RESULTSIn general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion.Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.CONCLUSIONReduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
Background Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. Methods A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. Results In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-[gamma] and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-[gamma]-induced protein (IP)-10 and monokine induced by IFN-[gamma]protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Conclusion Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-[gamma], may serve as key markers for indicating the treatment outcome.
Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. A total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system. In general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion. Reduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
Audience Academic
Author Jeong, Byeong-Ho
Park, Hye Yun
Kim, Yee Hyung
Cho, Sang-Nae
Shin, Sung Jae
Kim, Su-Young
Jeon, Kyeongman
Kim, Jong-Seok
Koh, Won-Jung
AuthorAffiliation 2 Department of Microbiology, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
University of Minnesota, United States of America
AuthorAffiliation_xml – name: University of Minnesota, United States of America
– name: 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
– name: 2 Department of Microbiology, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
Author_xml – sequence: 1
  givenname: Su-Young
  surname: Kim
  fullname: Kim, Su-Young
– sequence: 2
  givenname: Won-Jung
  surname: Koh
  fullname: Koh, Won-Jung
– sequence: 3
  givenname: Yee Hyung
  surname: Kim
  fullname: Kim, Yee Hyung
– sequence: 4
  givenname: Byeong-Ho
  surname: Jeong
  fullname: Jeong, Byeong-Ho
– sequence: 5
  givenname: Hye Yun
  surname: Park
  fullname: Park, Hye Yun
– sequence: 6
  givenname: Kyeongman
  surname: Jeon
  fullname: Jeon, Kyeongman
– sequence: 7
  givenname: Jong-Seok
  surname: Kim
  fullname: Kim, Jong-Seok
– sequence: 8
  givenname: Sang-Nae
  surname: Cho
  fullname: Cho, Sang-Nae
– sequence: 9
  givenname: Sung Jae
  surname: Shin
  fullname: Shin, Sung Jae
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25295870$$D View this record in MEDLINE/PubMed
BookMark eNqNk11r2zAUhs3oWNts_2BshsHYLpJJlr-0i0GXfQUyCl3YrTiWjxIF2fIsezT_fvLilKSUMXxhc_y875Fe6VwGZ7WtMQieUzKjLKPvtrZvazCzxpdnhBLOY_oouKCcRdM0Iuzs6Ps8uHRuS0jC8jR9EpxHScSTPCMXgVxUjW07qCWGVoU3KHXTWgkm_AjmUF2FczQmXFRVX-tuF-o6_L6TtgDZYav7KoTCSXSud-HcVo3B23DZ1-vwk3YIDp8GjxUYh8_G9yRYffm8mn-bLq-_LuZXy6lMedRN8zhVwGiSZnERSVmWZcHKhCeAlBdAkwIwjlSOGaZFwhKSJ6yISsplSkFCwSbBy71tY6wTYzxO0JRwRlnOuCcWe6K0sBVNqytod8KCFn8Ltl0LaDstDYpIAvhlqYxSHucY50qiKpVKYg4FycB7fRi79UWFpcS6a8GcmJ7-qfVGrO1vEVNOmD-TSfBmNGjtrx5dJyrtUzQ-dbT9sG5KsmQ4Jo--uoc-vLuRWoPfgK6V9X3lYCquYpqnLI7Toe3sAco_JVZa-ruktK-fCN6eCDzT4W23ht45sfhx8__s9c9T9vURu0Ew3cZZ03fa1u4UfHGc9F3Eh0vsgXgPyNY616K6QygRw6wc4hLDrIhxVrzs_T2Z1B0M7X0i2vxb_Ad-4hrR
CitedBy_id crossref_primary_10_1242_bio_019315
crossref_primary_10_1183_23120541_00590_2020
crossref_primary_10_1002_stem_2353
crossref_primary_10_1371_journal_ppat_1010454
crossref_primary_10_3390_ijms21186590
crossref_primary_10_1097_MCP_0000000000000665
crossref_primary_10_1093_jpids_piy047
crossref_primary_10_1128_spectrum_03110_22
crossref_primary_10_3390_jcm9051331
crossref_primary_10_3389_fimmu_2018_01319
crossref_primary_10_3389_fimmu_2019_00234
crossref_primary_10_3389_fimmu_2020_00303
crossref_primary_10_4046_trd_2017_80_2_153
crossref_primary_10_1007_s00430_015_0434_x
crossref_primary_10_3390_antibiotics11101322
crossref_primary_10_3904_kjm_2024_99_4_169
crossref_primary_10_4110_in_2021_21_e40
crossref_primary_10_1183_13993003_00250_2019
Cites_doi 10.1016/j.tube.2011.01.001
10.1371/journal.pone.0026363
10.1016/j.clim.2010.07.011
10.1586/erm.11.97
10.1164/rccm.200604-571ST
10.1371/journal.pone.0026545
10.1038/ni1449
10.1136/thx.2007.092205
10.1128/JCM.01175-12
10.1007/s10875-013-9978-y
10.1084/jem.187.1.129
10.1111/cei.12253
10.1186/1465-9921-14-138
10.1007/s00408-012-9411-y
10.1164/rccm.201003-0395OC
10.1165/rcmb.2009-0276TR
10.1016/j.tube.2012.06.005
10.1016/j.jinf.2013.08.005
10.1006/cyto.1999.0672
10.1371/journal.pone.0081560
10.5588/ijtld.14.0134
10.1111/j.1462-5822.2008.01151.x
10.4049/jimmunol.170.3.1174
10.1155/2010/347142
10.1183/09031936.00039507
10.1002/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6
10.1016/j.cytogfr.2010.10.004
10.1111/j.1752-8062.2010.00180.x
10.1093/jac/dkr578
10.1164/ajrccm.155.4.9105097
10.1016/S1472-9792(13)70005-2
10.1684/ecn.2014.0346
10.1086/318087
10.1093/intimm/dxh317
10.1007/s00408-007-9040-z
10.1093/rheumatology/ker316
10.1016/j.micinf.2004.09.004
10.1016/j.rmed.2011.05.017
10.1016/j.jinf.2012.11.005
ContentType Journal Article
Copyright COPYRIGHT 2014 Public Library of Science
2014 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2014 Kim et al 2014 Kim et al
Copyright_xml – notice: COPYRIGHT 2014 Public Library of Science
– notice: 2014 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2014 Kim et al 2014 Kim et al
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0109941
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Opposing Viewpoints
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
ProQuest Biological Science Collection
Agricultural Science Database
Health & Medical Collection (Alumni)
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest - Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals (WRLC)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Agricultural Science Database



MEDLINE - Academic




MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
DocumentTitleAlternate Cytokines and Chemokines in MABC Lung Disease
EISSN 1932-6203
ExternalDocumentID 1609313839
oai_doaj_org_article_2caac69f711948e48fcefdff549ab07a
PMC4190320
3455733631
A418634460
25295870
10_1371_journal_pone_0109941
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations South Korea
GeographicLocations_xml – name: South Korea
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PYCSY
RNS
RPM
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
3V.
BBORY
CGR
CUY
CVF
ECM
EIF
IPNFZ
NPM
PV9
RIG
RZL
PMFND
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
7X8
ESTFP
PUEGO
5PM
AAPBV
ABPTK
ID FETCH-LOGICAL-c692t-846fa315674b2ccdddb3d595ae19ba15bae42f8e7e6b5350853b2d19c61acab3
IEDL.DBID M48
ISSN 1932-6203
IngestDate Sun Sep 03 00:14:27 EDT 2023
Wed Aug 27 01:17:17 EDT 2025
Thu Aug 21 14:11:20 EDT 2025
Mon Sep 08 09:08:50 EDT 2025
Fri Jul 25 10:15:05 EDT 2025
Tue Jun 17 21:15:01 EDT 2025
Tue Jun 10 20:19:02 EDT 2025
Fri Jun 27 04:52:06 EDT 2025
Fri Jun 27 03:44:53 EDT 2025
Thu May 22 21:22:18 EDT 2025
Wed Feb 19 01:55:38 EST 2025
Tue Jul 01 04:13:50 EDT 2025
Thu Apr 24 22:55:18 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c692t-846fa315674b2ccdddb3d595ae19ba15bae42f8e7e6b5350853b2d19c61acab3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: WK SC SJS. Performed the experiments: SK JK. Analyzed the data: SK YHK SJS. Contributed reagents/materials/analysis tools: WK BJ HYP KJ. Contributed to the writing of the manuscript: SK WK YHK SJS.
Current address: Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0109941
PMID 25295870
PQID 1609313839
PQPubID 1436336
ParticipantIDs plos_journals_1609313839
doaj_primary_oai_doaj_org_article_2caac69f711948e48fcefdff549ab07a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4190320
proquest_miscellaneous_1610759587
proquest_journals_1609313839
gale_infotracmisc_A418634460
gale_infotracacademiconefile_A418634460
gale_incontextgauss_ISR_A418634460
gale_incontextgauss_IOV_A418634460
gale_healthsolutions_A418634460
pubmed_primary_25295870
crossref_primary_10_1371_journal_pone_0109941
crossref_citationtrail_10_1371_journal_pone_0109941
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2014-10-08
PublicationDateYYYYMMDD 2014-10-08
PublicationDate_xml – month: 10
  year: 2014
  text: 2014-10-08
  day: 08
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2014
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References I Bajoriuniene (ref26) 2012; 190
JJ Ellner (ref18) 2010; 3
MI Vargas-Rojas (ref24) 2011; 105
ED Chan (ref9) 2010; 43
YJ Ryu (ref12) 2007; 30
M Ruhwald (ref36) 2011; 91
R Lande (ref21) 2003; 170
KL Kellar (ref35) 2011; 6
R Nessar (ref3) 2012; 67
WJ Koh (ref8) 2011; 183
YS Kwon (ref13) 2007; 185
SY Kim (ref16) 2014; 176
TS Kim (ref11) 2014; 34
M Ruhwald (ref34) 2012; 12
A Azzurri (ref40) 2005; 7
C Lienhardt (ref14) 2002; 32
V Perna (ref30) 2013; 24
K Dheda (ref23) 2008; 63
DE Griffith (ref2) 2007; 175
E Torrado (ref22) 2010; 21
T Harada (ref7) 2012; 50
A Lim (ref15) 2010; 137
R Bonecchi (ref19) 1998; 187
N Santucci (ref29) 2011; 6
B Ten Berge (ref27) 2012; 51
DM Shin (ref10) 2008; 10
K Kurashima (ref20) 1997; 155
YJ Cho (ref6) 2013; 8
CL Daley (ref1) 2010; 14
M Armand (ref31) 2014; 68
A Mihret (ref32) 2013; 66
A Lim (ref39) 2010; 29
R Vankayalapati (ref17) 2001; 183
R Kushwah (ref25) 2013; 14
S Narumi (ref38) 2000; 12
X Wang (ref33) 2012; 92
ST Howard (ref4) 2013; 93
WJ Koh (ref5) 2014; 18
CW Wieland (ref28) 2005; 17
SA Khader (ref37) 2007; 8
17277290 - Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
23954615 - J Infect. 2014 Jan;68(1):62-70
18511642 - Thorax. 2008 Jun;63(6):566-8
21075039 - Cytokine Growth Factor Rev. 2010 Dec;21(6):455-62
20833823 - Am J Respir Crit Care Med. 2011 Feb 1;183(3):405-10
24312320 - PLoS One. 2013;8(11):e81560
20797909 - Clin Immunol. 2010 Nov;137(2):296-302
15716076 - Microbes Infect. 2005 Jan;7(1):1-8
17567674 - Eur Respir J. 2007 Oct;30(4):736-42
21459676 - Tuberculosis (Edinb). 2011 May;91(3):260-7
25216826 - Int J Tuberc Lung Dis. 2014 Oct;18(10):1141-8
22990520 - Lung. 2012 Oct;190(5):487-95
21045270 - Dis Markers. 2010;29(2):103-9
22022605 - PLoS One. 2011;6(10):e26363
22915613 - J Clin Microbiol. 2012 Nov;50(11):3556-61
10880246 - Cytokine. 2000 Jul;12(7):1007-16
12115643 - Eur J Immunol. 2002 Jun;32(6):1605-13
20443950 - Clin Transl Sci. 2010 Feb;3(1):23-8
17351619 - Nat Immunol. 2007 Apr;8(4):369-77
24354934 - Clin Exp Immunol. 2014 Apr;176(1):93-101
22075064 - Rheumatology (Oxford). 2012 Jan;51(1):37-46
22369377 - Expert Rev Mol Diagn. 2012 Mar;12(2):175-87
23178506 - J Infect. 2013 Apr;66(4):357-65
21763119 - Respir Med. 2011 Nov;105(11):1648-54
22132075 - PLoS One. 2011;6(11):e26545
24589429 - Eur Cytokine Netw. 2013 Oct-Dec;24(4):157-61
20487602 - Int J Tuberc Lung Dis. 2010 Jun;14(6):665-71
22290346 - J Antimicrob Chemother. 2012 Apr;67(4):810-8
16141243 - Int Immunol. 2005 Nov;17(11):1399-408
17926095 - Lung. 2007 Dec;185(6):337-41
24402617 - J Clin Immunol. 2014 Feb;34(2):212-23
9419219 - J Exp Med. 1998 Jan 5;187(1):129-34
12538673 - J Immunol. 2003 Feb 1;170(3):1174-82
22824465 - Tuberculosis (Edinb). 2012 Nov;92(6):513-20
24344776 - Respir Res. 2013;14:138
11133380 - J Infect Dis. 2001 Feb 1;183(3):478-84
20081053 - Am J Respir Cell Mol Biol. 2010 Oct;43(4):387-93
9105097 - Am J Respir Crit Care Med. 1997 Apr;155(4):1474-7
18373632 - Cell Microbiol. 2008 Aug;10(8):1608-21
24388643 - Tuberculosis (Edinb). 2013 Dec;93 Suppl:S15-20
References_xml – volume: 91
  start-page: 260
  year: 2011
  ident: ref36
  article-title: A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis
  publication-title: Tuberculosis (Edinb)
  doi: 10.1016/j.tube.2011.01.001
– volume: 6
  start-page: e26363
  year: 2011
  ident: ref29
  article-title: A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0026363
– volume: 137
  start-page: 296
  year: 2010
  ident: ref15
  article-title: Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2010.07.011
– volume: 12
  start-page: 175
  year: 2012
  ident: ref34
  article-title: IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions
  publication-title: Expert Rev Mol Diagn
  doi: 10.1586/erm.11.97
– volume: 175
  start-page: 367
  year: 2007
  ident: ref2
  article-title: An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200604-571ST
– volume: 6
  start-page: e26545
  year: 2011
  ident: ref35
  article-title: Multiple cytokines are released when blood from patients with tuberculosis is stimulated with Mycobacterium tuberculosis antigens
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0026545
– volume: 8
  start-page: 369
  year: 2007
  ident: ref37
  article-title: IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
  publication-title: Nat Immunol
  doi: 10.1038/ni1449
– volume: 63
  start-page: 566
  year: 2008
  ident: ref23
  article-title: Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis
  publication-title: Thorax
  doi: 10.1136/thx.2007.092205
– volume: 50
  start-page: 3556
  year: 2012
  ident: ref7
  article-title: Clinical and microbiological differences between Mycobacterium abscessus and Mycobacterium massiliense lung diseases
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.01175-12
– volume: 34
  start-page: 212
  year: 2014
  ident: ref11
  article-title: Mycobacterium massiliense induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinase
  publication-title: J Clin Immunol
  doi: 10.1007/s10875-013-9978-y
– volume: 187
  start-page: 129
  year: 1998
  ident: ref19
  article-title: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
  publication-title: J Exp Med
  doi: 10.1084/jem.187.1.129
– volume: 176
  start-page: 93
  year: 2014
  ident: ref16
  article-title: Changes in serum immunomolecules during antibiotic therapy for Mycobacterium avium complex lung disease
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12253
– volume: 14
  start-page: 138
  year: 2013
  ident: ref25
  article-title: Intrinsic predisposition of naive cystic fibrosis T cells to differentiate towards a Th17 phenotype
  publication-title: Respir Res
  doi: 10.1186/1465-9921-14-138
– volume: 14
  start-page: 665
  year: 2010
  ident: ref1
  article-title: Pulmonary non-tuberculous mycobacterial infections
  publication-title: Int J Tuberc Lung Dis
– volume: 190
  start-page: 487
  year: 2012
  ident: ref26
  article-title: Response of peripheral blood Th17 cells to inhaled Dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma
  publication-title: Lung
  doi: 10.1007/s00408-012-9411-y
– volume: 183
  start-page: 405
  year: 2011
  ident: ref8
  article-title: Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201003-0395OC
– volume: 43
  start-page: 387
  year: 2010
  ident: ref9
  article-title: Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2009-0276TR
– volume: 92
  start-page: 513
  year: 2012
  ident: ref33
  article-title: Diagnostic performance of multiplex cytokine and chemokine assay for tuberculosis
  publication-title: Tuberculosis (Edinb)
  doi: 10.1016/j.tube.2012.06.005
– volume: 68
  start-page: 62
  year: 2014
  ident: ref31
  article-title: Cytokine responses to quantiferon peptides in pediatric tuberculosis: a pilot study
  publication-title: J Infect
  doi: 10.1016/j.jinf.2013.08.005
– volume: 12
  start-page: 1007
  year: 2000
  ident: ref38
  article-title: TNF-alpha is a potent inducer for IFN-inducible protein-10 in hepatocytes and unaffected by GM-CSF in vivo, in contrast to IL-1beta and IFN-gamma
  publication-title: Cytokine
  doi: 10.1006/cyto.1999.0672
– volume: 8
  start-page: e81560
  year: 2013
  ident: ref6
  article-title: The genome sequence of ‘Mycobacterium massiliense’ strain CIP 108297 suggests the independent taxonomic status of the Mycobacterium abscessus complex at the subspecies level
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0081560
– volume: 18
  start-page: 1141
  year: 2014
  ident: ref5
  article-title: Advances in the management of pulmonary disease due to Mycobacterium abscessus complex
  publication-title: Int J Tuberc Lung Dis
  doi: 10.5588/ijtld.14.0134
– volume: 10
  start-page: 1608
  year: 2008
  ident: ref10
  article-title: Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2008.01151.x
– volume: 170
  start-page: 1174
  year: 2003
  ident: ref21
  article-title: IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.170.3.1174
– volume: 29
  start-page: 103
  year: 2010
  ident: ref39
  article-title: Immunological markers of lung disease due to non-tuberculous mycobacteria
  publication-title: Dis Markers
  doi: 10.1155/2010/347142
– volume: 30
  start-page: 736
  year: 2007
  ident: ref12
  article-title: Impaired expression of Toll-like receptor 2 in nontuberculous mycobacterial lung disease
  publication-title: Eur Respir J
  doi: 10.1183/09031936.00039507
– volume: 32
  start-page: 1605
  year: 2002
  ident: ref14
  article-title: Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo
  publication-title: Eur J Immunol
  doi: 10.1002/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6
– volume: 21
  start-page: 455
  year: 2010
  ident: ref22
  article-title: IL-17 and Th17 cells in tuberculosis
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2010.10.004
– volume: 3
  start-page: 23
  year: 2010
  ident: ref18
  article-title: Immunoregulation in TB: observations and implications
  publication-title: Clin Transl Sci
  doi: 10.1111/j.1752-8062.2010.00180.x
– volume: 67
  start-page: 810
  year: 2012
  ident: ref3
  article-title: Mycobacterium abscessus: a new antibiotic nightmare
  publication-title: J Antimicrob Chemother
  doi: 10.1093/jac/dkr578
– volume: 155
  start-page: 1474
  year: 1997
  ident: ref20
  article-title: Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/ajrccm.155.4.9105097
– volume: 93
  start-page: S15
  year: 2013
  ident: ref4
  article-title: Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex
  publication-title: Tuberculosis (Edinb)
  doi: 10.1016/S1472-9792(13)70005-2
– volume: 24
  start-page: 157
  year: 2013
  ident: ref30
  article-title: Effective treatment of pulmonary tuberculosis restores plasma leptin levels
  publication-title: Eur Cytokine Netw
  doi: 10.1684/ecn.2014.0346
– volume: 183
  start-page: 478
  year: 2001
  ident: ref17
  article-title: Cytokine profiles in immunocompetent persons infected with Mycobacterium avium complex
  publication-title: J Infect Dis
  doi: 10.1086/318087
– volume: 17
  start-page: 1399
  year: 2005
  ident: ref28
  article-title: Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxh317
– volume: 185
  start-page: 337
  year: 2007
  ident: ref13
  article-title: Decreased cytokine production in patients with nontuberculous mycobacterial lung disease
  publication-title: Lung
  doi: 10.1007/s00408-007-9040-z
– volume: 51
  start-page: 37
  year: 2012
  ident: ref27
  article-title: Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ker316
– volume: 7
  start-page: 1
  year: 2005
  ident: ref40
  article-title: IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2004.09.004
– volume: 105
  start-page: 1648
  year: 2011
  ident: ref24
  article-title: Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease
  publication-title: Respir Med
  doi: 10.1016/j.rmed.2011.05.017
– volume: 66
  start-page: 357
  year: 2013
  ident: ref32
  article-title: Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection
  publication-title: J Infect
  doi: 10.1016/j.jinf.2012.11.005
– reference: 24354934 - Clin Exp Immunol. 2014 Apr;176(1):93-101
– reference: 23178506 - J Infect. 2013 Apr;66(4):357-65
– reference: 24344776 - Respir Res. 2013;14:138
– reference: 24312320 - PLoS One. 2013;8(11):e81560
– reference: 21459676 - Tuberculosis (Edinb). 2011 May;91(3):260-7
– reference: 24388643 - Tuberculosis (Edinb). 2013 Dec;93 Suppl:S15-20
– reference: 20833823 - Am J Respir Crit Care Med. 2011 Feb 1;183(3):405-10
– reference: 9419219 - J Exp Med. 1998 Jan 5;187(1):129-34
– reference: 22369377 - Expert Rev Mol Diagn. 2012 Mar;12(2):175-87
– reference: 20081053 - Am J Respir Cell Mol Biol. 2010 Oct;43(4):387-93
– reference: 9105097 - Am J Respir Crit Care Med. 1997 Apr;155(4):1474-7
– reference: 22022605 - PLoS One. 2011;6(10):e26363
– reference: 22075064 - Rheumatology (Oxford). 2012 Jan;51(1):37-46
– reference: 17567674 - Eur Respir J. 2007 Oct;30(4):736-42
– reference: 20443950 - Clin Transl Sci. 2010 Feb;3(1):23-8
– reference: 21763119 - Respir Med. 2011 Nov;105(11):1648-54
– reference: 21045270 - Dis Markers. 2010;29(2):103-9
– reference: 15716076 - Microbes Infect. 2005 Jan;7(1):1-8
– reference: 18373632 - Cell Microbiol. 2008 Aug;10(8):1608-21
– reference: 23954615 - J Infect. 2014 Jan;68(1):62-70
– reference: 11133380 - J Infect Dis. 2001 Feb 1;183(3):478-84
– reference: 17351619 - Nat Immunol. 2007 Apr;8(4):369-77
– reference: 16141243 - Int Immunol. 2005 Nov;17(11):1399-408
– reference: 20487602 - Int J Tuberc Lung Dis. 2010 Jun;14(6):665-71
– reference: 12538673 - J Immunol. 2003 Feb 1;170(3):1174-82
– reference: 22915613 - J Clin Microbiol. 2012 Nov;50(11):3556-61
– reference: 22990520 - Lung. 2012 Oct;190(5):487-95
– reference: 17926095 - Lung. 2007 Dec;185(6):337-41
– reference: 24402617 - J Clin Immunol. 2014 Feb;34(2):212-23
– reference: 10880246 - Cytokine. 2000 Jul;12(7):1007-16
– reference: 25216826 - Int J Tuberc Lung Dis. 2014 Oct;18(10):1141-8
– reference: 20797909 - Clin Immunol. 2010 Nov;137(2):296-302
– reference: 22132075 - PLoS One. 2011;6(11):e26545
– reference: 17277290 - Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
– reference: 12115643 - Eur J Immunol. 2002 Jun;32(6):1605-13
– reference: 24589429 - Eur Cytokine Netw. 2013 Oct-Dec;24(4):157-61
– reference: 21075039 - Cytokine Growth Factor Rev. 2010 Dec;21(6):455-62
– reference: 18511642 - Thorax. 2008 Jun;63(6):566-8
– reference: 22824465 - Tuberculosis (Edinb). 2012 Nov;92(6):513-20
– reference: 22290346 - J Antimicrob Chemother. 2012 Apr;67(4):810-8
RelatedPersons Kim, Won
RelatedPersons_xml – fullname: Kim, Won
SSID ssj0053866
Score 2.272231
Snippet Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to...
Background Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was...
Background Little is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e109941
SubjectTerms Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biological response modifiers
Biology and Life Sciences
Care and treatment
Chemokines
Comparative analysis
Conversion
Critical care
Cystic fibrosis
Cytokines
Cytokines - blood
Defects
Defense mechanisms
Drug resistance
Female
Health aspects
Helper cells
Humans
Immune response
Immune system
Immunity
Immunity (Disease)
Immunology
Infection
Infections
Interferon
Interleukin 13
Interleukin 17
Interleukin 23
Interleukin 4
IP-10 protein
Kim, Won
Lung diseases
Lung Diseases - blood
Lung Diseases - drug therapy
Lung Diseases - immunology
Lymphocytes T
Male
Medicine
Medicine and Health Sciences
Microbiology
Middle Aged
Mycobacterium
Mycobacterium Infections, Nontuberculous - blood
Mycobacterium Infections, Nontuberculous - drug therapy
Mycobacterium Infections, Nontuberculous - immunology
Mycobacterium tuberculosis
Nontuberculous Mycobacteria - physiology
Patients
Sputum
Studies
T cells
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Tuberculosis
Tumor necrosis factor-TNF
Viral infections
γ-Interferon
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals (WRLC)
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBAgYhAYe0cZzY8bEgqhapIMGCeotsx4aVtsmK7Ertv--M440aVKkcuNrjaHde-SYefybkTYWcU5lQKStklham0anKHUslV7pqhM5yi6eRT7-I4x_F57Py7NpVX9gTNtADD4o7yK3WVigvGZTblSsqb51vvIe6RptMBmiUqWxbTA05GKJYiHhQjkt2EO2yv-patx82gwo2eREFvv4xK89Wy66_CXL-3Tl57VV0dJ_cixiSHg6_fYfcce0DshOjtKfvIpX0-4fEnpwHfA3jtPMUmSzwjQWLDbY0DqNzil_v6SKcFFlf0kVLTy8txHngcd6cUw25BYvynoYGdHdBl5AiaNzbeUTmR5_mH4_TeK1CCnrM1ykgDq851G2yMLm1TdMY3pSq1I4po1lptCtyXznphCk5ALiSm7xhygqmrTb8MZm1oMddQoUwqlQWOcgEPEso2SjvNJRQMMi8Twjfqri2kXIcb75Y1mEfTULpMWisRsPU0TAJScdVq4Fy4xb5D2i9URYJs8MAuFEd3ai-zY0S8hJtXw-nT8ewrw8LVgkONXOWkNdBAkkzWuzK-aU3fV-ffP35D0Lfv02E3kYh34E6rI4nIeA_IRnXRHJvIgmhbyfTu-ipW630NROZ4owD6IWVW--9efrVOI0PxU671nUblGGAIlVZyYQ8GZx91GyOu8KQ4BMiJ2EwUf10pl38DpzlBQBPnmdP_4etnpG7AFuLoRNzj8zWfzbuOUDDtXkRssAVK5lk9w
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9QwDI_gkBAviI2PFQYEhAQ8dGvaNGme0DY4dogDCQ60typNk3HSrT3WO4n999htrlA0Aa-JG7V27Ni1_QshzzLEnIqEChmXUciLUocqtiyUidJZKXQUG-xGnn4Qx1_4u5P0xP9wa3xZ5cYmtoa6rA3-I99nAmJvBvGUerX8HuKtUZhd9VdoXCXXGJw0uM-z8duNJQZdFsK3yyWS7Xvp7C3ryu61KSHOBsdRi9rf2-bRclE3lzmef9ZP_nYgjW-Rm96TpAed6LfIFVttk-tTnyvfJltebRv6wmNLv7xNzOSsdbhhnNaOgtM4xyMM1jnEGsdudEaP7GJBJ23ryOqCzis6vTCg-C2w8_qMajA2GKU3FM3Jwv6g78Fm0NddsucOmY3fzI6OQ3_PQmiEilchuCBOJxDISV7ExpRlWSRlqlJtmSo0SwtteewyK60o0gQ8ujQp4pIpI5g2ukjuklEFLN0hVIhCpcogKJmAtYSSpXJWQ0wFg8y5gCQbbufGY5DjVRiLvE2sSYhFOublKKPcyyggYf_UssPg-Af9IQqyp0UE7XagPj_NvULmsdEaPt9JxhTPLM-csa50DuJlXURSB-QxboO8a0ft7UB-wFkmEgiio4A8bSkQRaPCMp1TvW6afPLx638Qff40IHruiVwN7DDat0bANyE614Byd0AJtsAMpndw02640uS_tAae3Gzky6ef9NO4KJbeVbZeIw0Dt1KlmQzIvW7f95yNMU0MFj8gcqARA9YPZ6r5txbEnIMnmsTR_b-_1gNyAzxU3hVd7pLR6nxtH4IXuCoetar-E_FLXRw
  priority: 102
  providerName: ProQuest
Title Importance of Reciprocal Balance of T Cell Immunity in Mycobacterium abscessus Complex Lung Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/25295870
https://www.proquest.com/docview/1609313839
https://www.proquest.com/docview/1610759587
https://pubmed.ncbi.nlm.nih.gov/PMC4190320
https://doaj.org/article/2caac69f711948e48fcefdff549ab07a
http://dx.doi.org/10.1371/journal.pone.0109941
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdGJyFeEBsfC4xiEBLwkCrOhx0_ILSWlhXRgUY39S1yHGdU6tLStNL6wt_OXZJGBHWCFz_YZys-2-e73N3PhLwOEXPK4dJmvnBsP06ULV3DbOFJFSZcOa7GbOTRGT-98D9Pgske2b7ZWjEw32na4XtSF8tZ5-bn5gMc-PfFqw2CbTt1FvPMdApXD2ay78PdxNEcG_m1XwFON-dVAt1tPRsXVIHjX0vr1mI2z3epon9HVP5xRQ0ekPuVbklPys1wQPZMdkjujirv-SE5qA5yTt9WaNPvHhI9vC5mD_V0nlJQI6d4qcE4XYx6LGvHtGdmMzoskklWGzrN6GijQRQUUM_ra6pA_KDdnlMUMDNzQ7-AFKEfS_fPIzIe9Me9U7t6ecHWXLorG5SSVHlg2gk_drVOkiT2kkAGyjAZKxbEyvhuGhpheBx4oOMFXuwmTGrOlFax95i0MmDpEaGcxzKQGmHKOIzFpUhkahRYWVDJ0tQi3pbbka5QyfFxjFlUuNoEWCcl8yJco6haI4vYda9FicrxD_ouLmRNi5jaRcV8eRVVRzRytVIw_VQwJv3Q-GGqTZqkKVjQKnaEssgL3AZRmaBaS4boxGch98CsdizyqqBAXI0MA3eu1DrPo-HXy_8g-n7eIHpTEaVzYIdWVbIEzAnxuhqUxw1KkA660XyEm3bLlTxi3JEe80Avhp7bjby7-WXdjINiMF5m5mukYaBoyiAUFnlS7vuasy46juEOsIhonIgG65st2fRHAWvug27quc7T27_4GbkH-qpfhmAek9ZquTbPQSdcxW1yR0wElGGPYTn41Cb73f7Zt_N28ZelXYgBLH_1fwNtm2eI
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKIgEXRMujgUINAgGHtHEeTnxAqN1S7dLdIsEW9WY5jlNW2iZLsyvYH8V_ZCYvCKqAS6_2xErG429mMg8T8jzCnlMOFzbzQ8f240TZwjXMDj2hooQrx9VYjTw-5oMT__1pcLpGfjS1MJhW2WBiCdRJrvEf-S7j4Hsz8KfE2_lXG2-Nwuhqc4VGJRZHZvUNXLbizfAA9veF6x6-m_QHdn2rgK25cBc2KNxUeeC2hH7sap0kSewlgQiUYSJWLIiV8d00MqHhceCB_RJ4sZswoTlTWsUeLHuNXPc9j-MhivptRglAB-d1dZ4Xst1aGHbmeWZ2ygiUzzrar7wkoFUFvfksLy6zc_9M1_xN_x3eIbdrw5XuVZK2TtZMtkFujOvQ_AZZr1GioK_qVtav7xI9PC_texineUrBRp2ixoR19jGlshqd0L6ZzeiwrFRZrOg0o-OVBpwp-0gvz6kCbMOfAgVF9JqZ73QEEEUPqtjSPTK5ig24T3oZsHSTUM5jEQiNPdA4rMVFmIjUKHDhYJClqUW8httS1y3P8eaNmSzjeCG4PhXzJO6RrPfIInb71Lxq-fEP-n3cyJYWG3aXA_nFmazPv3S1UvD5aciY8CPjR6k2aZKm4J6r2AmVRbZRDGRV_drCjtzzWcQ98NkdizwrKbBpR4ZZQWdqWRRy-OHzfxB9-tghelkTpTmwQ6u6EgO-CZuBdSi3OpQAPbozvYlC23ClkL8OKTzZCPLl00_baVwUM_0yky-RhoEVK4IotMiDSu5bzroYlQYFY5GwcyI6rO_OZNMvZc90Hwxfz3Ue_v21tsnNwWQ8kqPh8dEjcguMY7_K99wivcXF0jwGA3QRPymPPSXyimHmJyF2mp4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkSouiJZHA4UaBAIOadd52PEBoXaXqku7BUFBvUWOY5dK22RpdgX70_h3zCTeQFAFXHq1J1YyHn8zk3mYkKcJ9pzqcemzSPT8KMuVLwPDfBFKleRc9QKN1cijI77_KXp7Ep8skR-LWhhMq1xgYg3UeanxH_k24-B7M_Cn5LZ1aRHvB3uvJ199vEEKI62L6zQaETkw82_gvlWvhgPY62dBsPfmuL_vuxsGfM1lMPVB-VoVggsjoizQOs_zLMxjGSvDZKZYnCkTBTYxwvAsDsGWicMsyJnUnCmtshCWvUaui1AIPFxJv80uARjh3FXqhYJtO8HYmpSF2aqjURHraML6woBWLSxPxmV1mc37Z-rmb7pw7xa56YxYutNI3SpZMsUaWRm5MP0aWXWIUdEXrq31y9tED89rWx_GaWkp2KtnqD1hnV1Mr2xGj2nfjMd0WFetTOf0rKCjuQbMqXtKz86pApzDHwQVRSQbm-_0EOCKDpo40x1yfBUbcJcsF8DSdUI5z2QsNfZD47AWlyKX1ihw52CQWeuRcMHtVLv253gLxzitY3oC3KCGeSnuUer2yCN--9Skaf_xD_pd3MiWFpt31wPlxWnqsCANtFLw-VYwJqPERInVxubWgquusp5QHtlEMUibStgWgtKdiCU8BP-955EnNQU28CjwKJyqWVWlw3ef_4Po44cO0XNHZEtgh1auKgO-CRuDdSg3OpQAQ7ozvY5Cu-BKlf46sPDkQpAvn37cTuOimPVXmHKGNAwsWhknwiP3GrlvORtghBqUjUdE50R0WN-dKc6-1P3TIzCCw6B3_--vtUlWAGDSw-HRwQNyA-zkqEn93CDL04uZeQi26DR7VJ96StIrRpmfSk-e1A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Importance+of+Reciprocal+Balance+of+T+Cell+Immunity+in+Mycobacterium+abscessus+Complex+Lung+Disease&rft.jtitle=PloS+one&rft.au=Su-Young%2C+Kim&rft.au=Won-Jung%2C+Koh&rft.au=Yee+Hyung+Kim&rft.au=Byeong-Ho+Jeong&rft.date=2014-10-08&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=9&rft.issue=10&rft_id=info:doi/10.1371%2Fjournal.pone.0109941&rft.externalDocID=1609313839
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon