The incidence of sore throat and group A streptococcal pharyngitis in children at high risk of developing acute rheumatic fever: A systematic review and meta-analysis

• Published in: PloS one Vol. 15; no. 11; p. e0242107
• Main Authors: Pearce, Sarah, Bowen, Asha C, Engel, Mark E, de la Lande, Maya, Barth, Dylan D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.11.2020; Public Library of Science (PLoS)
• Subjects: Aboriginal Australians; Adolescent; Antigens; Biology and Life Sciences; Cardiovascular diseases; Child; Child, Preschool; Children; Complications and side effects; Confidence intervals; Coronary artery disease; Demographic aspects; Developed countries; Diagnosis; Disease prevention; Epidemiology; Female; Fever; Grey literature; Health aspects; Health risks; Heart diseases; Humans; Incidence; Income; Infant; Infectious diseases; Male; Medical research; Medicine and Health Sciences; Meta-analysis; Pathogenesis; People and Places; Pharyngitis; Pharyngitis - complications; Pharyngitis - epidemiology; Pharynx; Physical Sciences; Research and Analysis Methods; Reviews; Rheumatic fever; Rheumatic Fever - epidemiology; Rheumatic heart disease; Risk; Risk factors; Social Sciences; Sore throat; Streptococcus; Streptococcus infections; Systematic review; Vaccines; Australia; Western Australia Australia

Group A streptococcal (GAS) pharyngitis has traditionally been considered the sole precursor of acute rheumatic fever (ARF). Evidence from Australia, however, suggests that GAS skin infections may contribute to the pathogenesis of ARF. A missing piece of evidence is the incidence of sore throat and...