LPS-Induced Lung Inflammation in Marmoset Monkeys – An Acute Model for Anti-Inflammatory Drug Testing

• Published in: PloS one Vol. 7; no. 8; p. e43709
• Main Authors: Seehase, Sophie, Lauenstein, Hans-Dieter, Schlumbohm, Christina, Switalla, Simone, Neuhaus, Vanessa, Förster, Christine, Fieguth, Hans-Gerd, Pfennig, Olaf, Fuchs, Eberhard, Kaup, Franz-Josef, Bleyer, Martina, Hohlfeld, Jens M., Braun, Armin, Sewald, Katherina, Knauf, Sascha
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2012; Public Library of Science (PLoS)
• Subjects: Aged; Alveoli; Aminopyridines - pharmacology; Aminopyridines - therapeutic use; Analysis; Animal models; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Benzamides - pharmacology; Benzamides - therapeutic use; Biology; Bronchoalveolar Lavage Fluid; Bronchus; Callithrix; Callithrix jacchus; Chronic obstructive pulmonary disease; Corticosteroids; Cyclopropanes - pharmacology; Cyclopropanes - therapeutic use; Cytokines; Development and progression; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical - methods; Drug therapy; Drugs; Female; Genetic aspects; Health aspects; Health care; Humans; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; In vivo methods and tests; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Inflammatory diseases; Inflammatory response; Inhibitors; Laboratory animals; Leukocytes (neutrophilic); Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lung - drug effects; Lung - metabolism; Lung - pathology; Lung diseases; Lung Diseases - chemically induced; Lung Diseases - drug therapy; Lung Diseases - metabolism; Lung Diseases - pathology; Lungs; Macrophage inflammatory protein; Macrophage inflammatory protein 1; Macrophages; Male; Medicine; Middle Aged; Model testing; Monkeys; Morbidity; Mortality; Neutrophils; Pathogenesis; Pathology; Phosphodiesterase; Phosphodiesterase 4 Inhibitors - pharmacology; Phosphodiesterase 4 Inhibitors - therapeutic use; Phylogenetics; Respiratory diseases; Respiratory distress syndrome; Rodents; Thoracic surgery; Toxicology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Veterinary Science; Germany

Increasing incidence and substantial morbidity and mortality of respiratory diseases requires the development of new human-specific anti-inflammatory and disease-modifying therapeutics. Therefore, new predictive animal models that closely reflect human lung pathology are needed. In the current study...