Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review

• Published in: PloS one Vol. 15; no. 12; p. e0244826
• Main Authors: Eberle, Claudia, Kirchner, Michaela F., Herden, Raphaela, Stichling, Stefanie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.12.2020; Public Library of Science (PLoS)
• Subjects: Age; Animal models; Biology and Life Sciences; Birth weight; Birth Weight - genetics; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - genetics; Cigarette smoke; Demographic aspects; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diseases; DNA methylation; Environmental conditions; Epidemiology; Epigenesis, Genetic; Epigenetics; Exposure; Fathers; Female; Fetal Development - physiology; Fetuses; Genetic aspects; Genotype & phenotype; Health aspects; Health risks; High fat diet; High protein diet; Humans; Hyperglycemia; Hypotheses; Insulin resistance; Internal medicine; Intrauterine exposure; Literature reviews; Low fat diet; Low protein diet; Male; Malnutrition; Medicine; Medicine and Health Sciences; Metabolic diseases; Metabolic Diseases - genetics; Metabolic disorders; Nutrient deficiency; Nutrition; Nutrition research; Obesity; Offspring; Parental influences; Programming; Risk analysis; Risk Factors; Smoke; Social Sciences; Specialization; Sperm; Subject heading schemes; Undernutrition; Germany

There is lots of evidence that maternal peri-gestational metabolic, genomic and environmental conditions are closely linked to metabolic and cardiovascular outcomes in their offspring later in life. Moreover, there is also lotsof evidence that underlining mechanisms, such as molecular as well as epi...