A clinical method for estimating the modulus of elasticity of the human cornea in vivo

• Published in: PloS one Vol. 15; no. 1; p. e0224824
• Main Author: Pye, David C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.01.2020; Public Library of Science (PLoS)
• Subjects: Adult; Algorithms; Biology and Life Sciences; Biomechanics; Calibration; Contact lenses; Cornea; Cornea - diagnostic imaging; Cornea - physiology; Corneal Diseases - diagnosis; Corneal Diseases - diagnostic imaging; Corneal Diseases - physiopathology; Corneal Pachymetry - methods; Elasticity; Elasticity - physiology; Engineering and Technology; Female; Humans; In vivo methods and tests; Instrumentation; Instruments; Intraocular pressure; Intraocular Pressure - physiology; Male; Mathematical analysis; Mechanical properties; Medicine and Health Sciences; Methods; Microscopy; Modulus of elasticity; Ocular Hypertension - diagnosis; Ocular Hypertension - diagnostic imaging; Ocular Hypertension - physiopathology; Physical Sciences; Regression analysis; Research and Analysis Methods; Social Sciences; Stiffness; Studies; Surgical techniques; Tonometry, Ocular - methods
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0224824

To develop a method, using current clinical instrumentation, to estimate the Young's modulus of the human cornea in vivo. Central corneal curvature (CCC), central corneal thickness(CCT), intraocular pressure (IOP) was measured with the Goldmann tonometer (IOPG) and the Pascal Dynamic Corneal To...