Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment

• Published in: PloS one Vol. 9; no. 10; p. e111685
• Main Authors: Martínez-Martínez, Narcisa, Martínez-Alonso, Emma, Ballesta, José, Martínez-Menárguez, José A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.10.2014; Public Library of Science (PLoS)
• Subjects: Acids; Analysis; Biology; Biology and Life Sciences; Brefeldin A; Depletion; Employee recruitment; Endoplasmic reticulum; Enzymatic activity; Enzymes; Golgi apparatus; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - metabolism; HeLa Cells; Histology; Humans; Kinases; Lipids; Low temperature; Medical schools; Membranes; Molecular modelling; Overexpression; Phosphatidic acid; Phosphatidic Acids - metabolism; Phospholipase; Phospholipase D - antagonists & inhibitors; Phospholipase D - genetics; Phospholipase D - metabolism; Phospholipase D2; Phospholipases; Physiological aspects; Protein Transport; Proteins; Recruitment; Regulation; trans-Golgi Network - metabolism; Transport; Tubules; Spain

Lipids and lipid-modifying enzymes play a key role in the biogenesis, maintenance and fission of transport carriers in the secretory and endocytic pathways. In the present study we demonstrate that phosphatidic acid generated by phospholipase D2 (PLD2) is involved in the formation of Golgi tubules....