How to Kill the Honey Bee Larva: Genomic Potential and Virulence Mechanisms of Paenibacillus larvae

• Published in: PloS one Vol. 9; no. 3; p. e90914
• Main Authors: Djukic, Marvin, Brzuszkiewicz, Elzbieta, Fünfhaus, Anne, Voss, Jörn, Gollnow, Kathleen, Poppinga, Lena, Liesegang, Heiko, Garcia-Gonzalez, Eva, Genersch, Elke, Daniel, Rolf
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.03.2014; Public Library of Science (PLoS)
• Subjects: Air bases; American foulbrood; Animals; Apis mellifera; Bacteria; Bacterial Proteins - metabolism; Bacterial Toxins - genetics; Base Composition - genetics; Bees; Bees - microbiology; Biology; Biosynthetic Pathways - genetics; Chromosomes, Bacterial - genetics; Clustered Regularly Interspaced Short Palindromic Repeats - genetics; Collagen; European honeybee; Gene mutation; Gene transfer; Genes; Genetic aspects; Genetic Loci; Genome, Bacterial - genetics; Genomes; Genomic Islands - genetics; Genomics; Genotypes; Honey; Infectious diseases; Larva - microbiology; Larvae; Loci; Models, Biological; Multigene Family; Mutation; Nucleotide sequence; Paenibacillus; Paenibacillus - genetics; Paenibacillus - pathogenicity; Pathogenicity; Pathogens; Peptides; Phages; Polyketides; Proteins; Strains (organisms); Toxins; Virulence; Virulence (Microbiology); Virulence - genetics; Virulence factors

Paenibacillus larvae, a Gram positive bacterial pathogen, causes American Foulbrood (AFB), which is the most serious infectious disease of honey bees. In order to investigate the genomic potential of P. larvae, two strains belonging to two different genotypes were sequenced and used for comparative...