Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease

• Published in: PloS one Vol. 10; no. 6; p. e0128651
• Main Authors: Dijkstra, Anke A., Ingrassia, Angela, de Menezes, Renee X., van Kesteren, Ronald E., Rozemuller, Annemieke J. M., Heutink, Peter, van de Berg, Wilma D. J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.06.2015; Public Library of Science (PLoS)
• Subjects: Aged; Analysis; Autophagy; Axon guidance; Axons - physiology; Behavior disorders; Brain research; Case-Control Studies; Cell survival; Clathrin; Cloning; Degeneration; Deregulation; Disease Progression; Dopamine receptors; Endocytosis; Endocytosis - physiology; Eukaryotic Initiation Factor-2 - physiology; Family medical history; Female; Gene expression; Genomics; Humans; Immune response; Immune system; In Situ Hybridization; Lewy bodies; Lewy body disease; Lewy Body Disease - physiopathology; Male; Molecular chains; Molecular modelling; Morphology; Movement disorders; Mutation; Neurodegeneration; Neurodegenerative diseases; Neurosciences; Oligonucleotide Array Sequence Analysis; Parkinson Disease - immunology; Parkinson Disease - physiopathology; Parkinson's disease; Pathogenesis; Pathology; Proteins; Signal transduction; Signal Transduction - physiology; Signaling; Substantia nigra; Substantia Nigra - immunology; Substantia Nigra - physiopathology; Synuclein; Thrombin; TOR protein; TOR Serine-Threonine Kinases - physiology; San Francisco California; Netherlands; California; United States > US

Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson's disease (PD). To elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of PD, we investigated the transcriptome of the substantia nigra...