CHARM: COVID-19 Health Action Response for Marines–Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test

• Published in: PloS one Vol. 17; no. 4; p. e0266691
• Main Authors: Sedegah, Martha, Porter, Chad, Hollingdale, Michael R., Ganeshan, Harini, Huang, Jun, Goforth, Carl W., Belmonte, Maria, Belmonte, Arnel, Weir, Dawn L., Lizewski, Rhonda A., Lizewski, Stephen E., Sealfon, Stuart C., Jani, Vihasi, Cheng, Ying, Inoue, Sandra, Velasco, Rachael, Villasante, Eileen, Sun, Peifang, Letizia, Andrew G.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.04.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Antibodies, Viral; Antigenic determinants; Antigens; Asymptomatic; Asymptomatic Infections; Biology and Life Sciences; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - immunology; COVID-19 Vaccines; Enrollments; Epitopes; Evaluation; FDA approval; Humans; Immune response; Immune system; Infections; Interferon; Interferon-gamma - immunology; Interleukin 2; Interleukin-2 - immunology; Lymphocytes; Lymphocytes T; Medical research; Medical tests; Medicine and Health Sciences; Methods; Military Personnel; N protein; Nucleocapsids; Peptides; Pools; Proteins; SARS-CoV-2 - genetics; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Vaccines; Viral diseases; Virology; γ-Interferon; United States; United States > US; Peru

SARS-CoV-2 T cell responses are associated with COVID-19 recovery, and Class I- and Class II-restricted epitopes have been identified in the spike (S), nucleocapsid (N) and membrane (M) proteins and others. This prospective COVID-19 Health Action Response for Marines (CHARM) study enabled assessment...