The transcriptional regulation of the human angiotensinogen gene after high-fat diet is haplotype-dependent: Novel insights into the gene-regulatory networks and implications for human hypertension

• Published in: PloS one Vol. 12; no. 5; p. e0176373
• Main Authors: Rana, Anita, Jain, Sudhir, Puri, Nitin, Kaw, Meenakshi, Sirianni, Natalie, Eren, Deniz, Mopidevi, Brahma Raju, Kumar, Ashok
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.05.2017; Public Library of Science (PLoS)
• Subjects: Adipose tissue; Aldosterone; Angiotensin; Angiotensinogen; Angiotensinogen - genetics; Animal tissues; Binding; Biology and life sciences; Blood; Blood pressure; Care and treatment; Chromatin; Cytokines; Development and progression; Diet; Diet, High-Fat; Gene expression; Gene Expression Regulation; Gene regulation; Gene Regulatory Networks; Genetic aspects; Genetic regulation; Haplotypes; Health aspects; High fat diet; Humans; Hypertension; Hypertension - genetics; Identification and classification; Kinases; Liver; Medicine and Health Sciences; Mice; Obesity; Pharmacology; Physiology; Plasma levels; Proteins; Renin; Rodents; Signal transduction; Single-nucleotide polymorphism; Stat3 protein; Transcription factors; Transcription, Genetic; Transgenic mice; New York; United States > US; Ohio

Single nucleotide polymorphisms (SNPs) in the human angiotensinogen (hAGT) gene may modulate its transcription and affect the regulation of blood pressure via activation of the renin-angiotensin aldosterone system (RAAS). In this regard, we have identified polymorphisms in the 2.5 Kb promoter of the...