Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

• Published in: PloS one Vol. 11; no. 3; p. e0150792
• Main Authors: Thornley, Thomas B, Agarwal, Krishna A, Kyriazis, Periklis, Ma, Lingzhi, Chipashvili, Vaja, Aker, Jonathan E, Korniotis, Sarantis, Csizmadia, Eva, Strom, Terry B, Koulmanda, Maria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.03.2016; Public Library of Science (PLoS)
• Subjects: Abundance; Adaptive immunity; Adaptive systems; Animals; Antigens; Antigens, CD - metabolism; Biology and Life Sciences; Comparative analysis; Cytokines; Dendritic cells; Dendritic Cells - immunology; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - pathology; Female; Forkhead Transcription Factors - metabolism; Foxp3 protein; Genetic aspects; Genomes; Genotype & phenotype; Glucose; Immune response; Immune system; Immunity; Immunology; Immunoregulation; Immunostimulation; Inflammation; Innate immunity; Islets of Langerhans - pathology; Laboratory animals; Macrophages; Macrophages - immunology; Medical schools; Medicine; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Monocytes; Pathogenesis; Phenotype; Physiological aspects; Real-Time Polymerase Chain Reaction; Relative abundance; Rodents; Surgery; T-Lymphocytes, Regulatory - immunology; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Transgenic animals; Type 1 diabetes; United States; United States > US; Massachusetts

The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role of their tissue-resident counterparts remains undefined. We now demonstrate tha...