Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons

• Published in: PloS one Vol. 10; no. 4; p. e0122220
• Main Authors: Jacobson, Else, Jacobsen, Else, Dart, Andrew J, Mondori, Takamitsu, Horadogoda, Neil, Jeffcott, Leo B, Little, Christopher B, Smith, Margaret M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.04.2015; Public Library of Science (PLoS)
• Subjects: Aggrecan; Analysis; Animals; Biomechanics; Collagen; Enzymes; Euthanasia; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Gene Expression; Histopathology; Horse Diseases - genetics; Horse Diseases - metabolism; Horse Diseases - pathology; Horses; Horses - genetics; Horses - injuries; Horses - metabolism; Immunohistochemistry; Injuries; Knee; Laboratories; Male; Medical research; Models, Biological; Pathology; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; Rotator cuff; Surgery; Teaching hospitals; Tendinopathy - genetics; Tendinopathy - metabolism; Tendinopathy - veterinary; Tendon Injuries - genetics; Tendon Injuries - metabolism; Tendon Injuries - veterinary; Tendons; Tendons - metabolism; Tendons - pathology; Tissue inhibitor of metalloproteinase 1; Tissue inhibitor of metalloproteinase 3; Versican; Australia; New South Wales Australia

It is not known how extensively a localised flexor tendon injury affects the entire tendon. This study examined the extent of and relationship between histopathologic and gene expression changes in equine superficial digital flexor tendon after a surgical injury. One forelimb tendon was hemi-transec...