Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice

• Published in: PloS one Vol. 8; no. 9; p. e75346
• Main Authors: Elliott, Ruth, Li, Fan, Dragomir, Isabelle, Chua, Ming Ming W, Gregory, Brian D, Weiss, Susan R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.09.2013; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Analysis; Animals; Antigen presentation; Antiviral agents; Biocompatibility; Biology; Biomedical materials; Bone marrow; Catabolism; Central nervous system; Coronaviridae; Coronavirus Infections - metabolism; Coronavirus Infections - pathology; Coronaviruses; Cytokines; Cytokines - biosynthesis; Cytokines - metabolism; DAP12 protein; Demyelinating Diseases - metabolism; Demyelinating Diseases - pathology; Demyelinating Diseases - virology; Demyelination; Female; Fibroblasts; Gene expression; Genes; Genetic aspects; Health aspects; Hepatitis; Immune clearance; Infection; Infections; Infiltration; Information systems; Laboratory animals; Lipid metabolism; Lipids; Lymphocytes; Lymphocytes T; Macrophages; Male; Medicine; Membrane Glycoproteins - biosynthesis; Metabolism; Mice; Microglia; Multiple sclerosis; Murine hepatitis virus - metabolism; Myelin; Nerve Tissue Proteins - biosynthesis; Nervous system; Nervous system diseases; Neurodegenerative diseases; Neurological diseases; Next-generation sequencing; Osteoclasts; Persistent infection; Phosphatase; Physiological aspects; Reabsorption; Receptors, Immunologic - biosynthesis; Ribonucleic acid; RNA; Rodents; Spinal cord; Spinal Cord - metabolism; Spinal Cord - pathology; Th1 Cells - metabolism; Th1 Cells - pathology; Transcription; Transcriptome; Virus diseases; Viruses; United States > US; Pennsylvania

Persistent infection of the mouse central nervous system (CNS) with mouse hepatitis virus (MHV) induces a demyelinating disease pathologically similar to multiple sclerosis and is therefore used as a model system. There is little information regarding the host factors that correlate with and contrib...