Low Prognostic Nutritional Index Correlates with Worse Survival in Patients with Advanced NSCLC following EGFR-TKIs

• Published in: PloS one Vol. 11; no. 1; p. e0147226
• Main Authors: Sheng, Jin, Yang, Yun-Peng, Ma, Yu-Xiang, Qin, Tao, Hu, Zhi-Huang, Hong, Shao-Dong, Zhou, Ting, Huang, Yan, Zhao, Hong-Yun, Zhang, Li
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.01.2016; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; c-Met protein; C-reactive protein; Cancer patients; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Cell number; Collaboration; Correlation; Development and progression; Dosage and administration; Drug therapy; Enzyme inhibitors; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; Female; Food and nutrition; Humans; Inflammation; Laboratories; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - drug therapy; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lymphocytes; Male; Medical prognosis; Medicine; Metastasis; Middle Aged; Multivariate analysis; Mutation; Neoplasm Staging; Non-small cell lung carcinoma; Nutrition Assessment; Nutritional Status; Oncology; Patient outcomes; Patients; Pilot Projects; Prognosis; Protein Kinase Inhibitors - therapeutic use; Protein-tyrosine kinase; Quality of life; Retrospective Studies; Serum albumin; Survival; Survival Rate; Tyrosine; China

This study was designed to demonstrate the prognostic value of prognostic nutritional index (PNI), a reflection systemic immunonutritional status, on the long-term survival of patients taking epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs). In this retrospective study, elig...