Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes

• Published in: PloS one Vol. 10; no. 4; p. e0123256
• Main Authors: Zhang, Chengcheng, Yu, Haining, Ni, Xiaofeng, Shen, Shengrong, Das, Undurti N.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.04.2015; Public Library of Science (PLoS)
• Subjects: 5-Fluorouracil; Antimetabolites, Antineoplastic - pharmacology; Apoptosis; Arachidonate 5-Lipoxygenase - metabolism; Arthritis; Cancer; Cancer cells; Cell culture; Cell Line, Tumor; Colon; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Composition; Cyclooxygenase 2 - metabolism; Cyclooxygenase-2; Cytotoxicity; Dinoprostone - biosynthesis; Engineering; Fatty acid composition; Fatty acids; Fatty Acids - metabolism; Fatty Acids, Unsaturated - pharmacology; Fluorouracil; Fluorouracil - pharmacology; Food science; Gene Expression Regulation, Neoplastic - drug effects; Growth; Humans; Intramolecular Oxidoreductases - genetics; Intramolecular Oxidoreductases - metabolism; Leukotriene B4 - biosynthesis; Leukotrienes; Lipocalins - genetics; Lipocalins - metabolism; Lipoxin A4; Lipoxins - biosynthesis; Lupus; Metabolites; Multiple sclerosis; Polyunsaturated fatty acids; Prostaglandin E; Prostaglandin E2; Prostaglandin-E Synthases; Prostaglandins; Supplements; Synthesis; Synthetic prostaglandins E; Unsaturated fatty acids; United States > US; China

Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cancer cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) and lipoxins (LXs) play a significant role in colon cancer. Human colon cancer LoVo and RKO...