Limited field radiation therapy results in decreased bone fracture toughness in a murine model

• Published in: PloS one Vol. 13; no. 10; p. e0204928
• Main Authors: Bartlow, Christopher M, Mann, Kenneth A, Damron, Timothy A, Oest, Megan E
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.10.2018; Public Library of Science (PLoS)
• Subjects: Advanced glycosylation end products; Age; Animal models; Animals; Biochemistry; Biology and Life Sciences; Biomechanical Phenomena; Biomechanics; Bone composition; Bone density; Bone mineral density; Bone surgery; Bones; Collagen; Cortical bone; Crack propagation; Disease Models, Animal; Embrittlement; Experiments; Female; Femoral Fractures - etiology; Femoral Fractures - metabolism; Femoral Fractures - physiopathology; Femur; Fracture toughness; Fractures; Fragility; Glycation End Products, Advanced - metabolism; Glycosylation; Health aspects; Irradiation; Joint surgery; Knee; Laboratory animals; Mechanical properties; Medicine and Health Sciences; Mice; Morphology; Murinae; Orthopedics; Post-irradiation; Radiation; Radiation damage; Radiation effects; Radiation therapy; Radiotherapy; Radiotherapy - adverse effects; Research and Analysis Methods; Ribosylation; Studies; X-Ray Microtomography; New York; United States > US

Fragility fractures are a well-known complication following oncologic radiotherapy, and it is suspected that radiation-induced embrittlement of bone within the treatment field may contribute to fracture risk. To explore this phenomenon, a mouse model (BALB/cJ) of fractionated, limited field, bilater...