The Effects of Lung Protective Ventilation or Hypercapnic Acidosis on Gas Exchange and Lung Injury in Surfactant Deficient Rabbits

• Published in: PloS one Vol. 11; no. 2; p. e0147807
• Main Authors: Hummler, Helmut D., Banke, Katharina, Wolfson, Marla R., Buonocore, Giuseppe, Ebsen, Michael, Bernhard, Wolfgang, Tsikas, Dimitrios, Fuchs, Hans
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.02.2016; Public Library of Science (PLoS)
• Subjects: Acidosis; Acidosis, Respiratory - etiology; Acidosis, Respiratory - physiopathology; Alveoli; Analysis; Animal models; Animals; Biology and Life Sciences; Biomarkers; Blood Gas Analysis; Bronchoalveolar lavage; Bronchoalveolar Lavage Fluid; Bronchus; Carbon dioxide; Critical care; Disease Models, Animal; Drug therapy; Engineering and Technology; Gas exchange; Hemodynamics; Histology; Hospitals; Hypercapnia; Hypercapnia - complications; Hypoventilation; Inflammation; Inflammatory response; Injury prevention; Interleukin; Interleukin 8; Laboratory animals; Lactic acid; Lung Injury - blood; Lung Injury - etiology; Lung Injury - pathology; Lung Injury - prevention & control; Lung Injury - therapy; Lungs; Mechanical ventilation; Medicine and Health Sciences; Newborn babies; Pediatric respiratory diseases; Pediatrics; pH effects; Physical Sciences; Pulmonary Surfactants; Rabbits; Respiration, Artificial - methods; Respiratory distress syndrome; Rodents; Surface active agents; Surfactants; Tidal Volume; Ventilation; Ventilators; Germany

Permissive hypercapnia has been shown to reduce lung injury in subjects with surfactant deficiency. Experimental studies suggest that hypercapnic acidosis by itself rather than decreased tidal volume may be a key protective factor. To study the differential effects of a lung protective ventilatory s...