A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy

• Published in: PloS one Vol. 7; no. 5; p. e34824
• Main Authors: Zheng, Min, Lv, Lin-Li, Cao, Yu-Han, Liu, Hong, Ni, Jie, Dai, Hou-Yong, Liu, Dan, Lei, Xiang-Dong, Liu, Bi-Cheng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.05.2012; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Biology; Biomarkers; Biomarkers - urine; Clinical medicine; Connective tissue growth factor; Diabetes; Diabetes mellitus; Diabetic nephropathies; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - genetics; Diabetic Nephropathies - urine; Diabetic nephropathy; E-cadherin; Epidermal growth factor receptors; Female; Gene expression; Gene Expression Profiling; Genes; Genetic research; Growth factors; Hospitals; Humans; Kidney diseases; Kidney transplantation; Laboratories; Male; Mass Screening; Medical research; Medicine; Messenger RNA; Microarray Analysis; Middle Aged; Monocyte chemoattractant protein 1; Nephrology; Nephropathy; Patients; Pilot Projects; Polyamide-imides; Relative abundance; Reproducibility of Results; RNA, Messenger - urine; Rodents; Searching; Sediments; Sensitivity and Specificity; Studies; Tissue inhibitor of metalloproteinase 1; Type 2 diabetes; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0034824

The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment has emerged as a novel strategy for studying renal diseases. Considering the numerous molecules involved in DN development, a high-throughput platform with parallel detection...