Association between Arterial Stiffness and Serum L-Octanoylcarnitine and Lactosylceramide in Overweight Middle-Aged Subjects: 3-Year Follow-Up Study

• Published in: PloS one Vol. 10; no. 3; p. e0119519
• Main Authors: Kim, Minjoo, Jung, Saem, Lee, Sang-Hyun, Lee, Jong Ho
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.03.2015; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Ankle; Antigens, CD - blood; Blood Pressure; Body mass; Body Mass Index; Body weight; Cardiovascular diseases; Carnitine - analogs & derivatives; Carnitine - blood; Case-Control Studies; Cholesterol; Comparative analysis; Fatty acids; Glucose; Health risks; High density lipoprotein; Humans; Insulin; Insulin resistance; L-leucine; Lactosylceramides - blood; Leucine; Leucine - blood; Lipoproteins (high density); Mass spectrometry; Mass spectroscopy; Metabolites; Middle Aged; Morbidity; Mortality; Mortality risk; Nutrition; Obesity; Overweight; Overweight - complications; Regression analysis; Rodents; Stiffness; Triglycerides; Vascular Stiffness; Wave velocity; Japan

Existing data on the association between being overweight and cardiovascular morbidity and mortality risk in adults are inconsistent. We prospectively and longitudinally investigated the effects of weight on arterial stiffness and plasma metabolites in middle-aged subjects (aged 40-55 years). A grou...