Total polyphenols and antihyperglycemic activity of aqueous fruits extract of Abelmoschus esculentus: Modeling and optimization of extraction conditions

• Published in: PloS one Vol. 16; no. 4; p. e0250405
• Main Authors: Peter, Emanuel L, Nagendrappa, Prakash B, Ajayi, Clement Olusoji, Sesaazi, Crispin Duncan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.04.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Animal models; Animals; Biology and Life Sciences; Carbohydrates; Design of experiments; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Experimental - drug therapy; Ethanol; Flavonoids; Fruit; Fruits; Gardens & gardening; High temperature; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - isolation & purification; Male; Medical research; Medicine and Health Sciences; Model testing; Ninhydrin; Okra; Optimization; Pharmacy; Physical Sciences; Phytochemicals; Phytochemicals - administration & dosage; Phytochemicals - isolation & purification; Plant Extracts - administration & dosage; Plant Extracts - isolation & purification; Polyphenols; Polyphenols - administration & dosage; Polyphenols - isolation & purification; Proteins; Rats; Rats, Wistar; Reagents; Research and Analysis Methods; Seeds; Solvents; Temperature rise; India; Uganda; Tanzania

Aqueous fruits extract of Abelmoschus esculentus (L.) Moench (Malvaceae) has been used traditionally in several communities to alleviate elevated blood glucose levels. However, optimized extraction conditions have not been reported. Thus, this study determined the optimal extraction conditions for e...