Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

• Published in: PloS one Vol. 9; no. 8; p. e105897
• Main Authors: Sánchez, Carlos, Bueno-Orovio, Alfonso, Wettwer, Erich, Loose, Simone, Simon, Jana, Ravens, Ursula, Pueyo, Esther, Rodriguez, Blanca
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.08.2014; Public Library of Science (PLoS)
• Subjects: Action potential; Action Potentials; Adenosine triphosphatase; Analysis; Atrial fibrillation; Atrial Fibrillation - physiopathology; Atrioventricular Node - physiopathology; Bioengineering; Biology and Life Sciences; Biomedical materials; Biomedical research; Calibration; Cardiac arrhythmia; Cell culture; Chronic Disease; Computer and Information Sciences; Computer applications; Computer science; Conductance; Electrophysiology; Engineering and Technology; Engineering research; Fibrillation; Heart Conduction System; Heart failure; Humans; Mathematical models; Medical research; Medical treatment; Medicine and Health Sciences; Morphology; Myocardial Contraction; Patients; Pharmacology; Populations; Research and Analysis Methods; Resistance; Rhythm; Sinoatrial Node - physiopathology; Sinuses; Studies; Thyroid gland; Toxicology; Triangulation; Variability; United Kingdom > UK; Germany; Spain

Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying...