CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs

The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in...

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Published inPloS one Vol. 7; no. 10; p. e46995
Main Authors Kos, Miriam, van den Brink, Danielle, Snijders, Tineke M., Rijpkema, Mark, Franke, Barbara, Fernandez, Guillen, Hagoort, Peter
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 24.10.2012
Public Library of Science (PLoS)
Subjects
Adolescent
Adult
Adults
Autism
Biology
Brain
Carriers
Cell adhesion & migration
Child & adolescent psychiatry
Cognition & reasoning
Electroencephalography
Event-related potentials
Evoked Potentials
Foxp2 protein
Homozygotes
Humans
Information processing
Language
Linguistics
Medicine
Membrane Proteins - genetics
Membrane Proteins - physiology
Mutation
Natural language processing
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neurosciences
NMR
Nuclear magnetic resonance
Proteins
Reading comprehension
Reference Values
Semantics
Skills
Social and Behavioral Sciences
Studies
Young Adult
Netherlands
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ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0046995

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Abstract The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
AbstractList The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
Audience Academic
Author Kos, Miriam
Fernandez, Guillen
van den Brink, Danielle
Franke, Barbara
Snijders, Tineke M.
Rijpkema, Mark
Hagoort, Peter
AuthorAffiliation 1 Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
6 Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
8 Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
5 Department of Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
7 Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
3 Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
2 Radboud University Nijmegen, Behavioural Science Institute, Nijmegen, The Netherlands
The University of Western Australia, Australia
4 Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
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2012 Kos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2012 Kos et al 2012 Kos et al
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– notice: 2012 Kos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Conceived and designed the experiments: MK PH DVDB TMS. Performed the experiments: MK. Analyzed the data: MK DVDB. Contributed reagents/materials/analysis tools: MK BF MR GF. Wrote the paper: MK DVDB PH. Genotyping of participants/contributed genetic analysis tools: BF MR GF.
Competing Interests: The authors have declared that no competing interests exist.
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PublicationPlace United States
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PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2012
Publisher Public Library of Science
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– reference: 20838614 - PLoS One. 2010;5(9):e12633
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Snippet The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is...
The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is...
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StartPage e46995
SubjectTerms Adolescent
Adult
Adults
Autism
Biology
Brain
Carriers
Cell adhesion & migration
Child & adolescent psychiatry
Cognition & reasoning
Electroencephalography
Event-related potentials
Evoked Potentials
Foxp2 protein
Homozygotes
Humans
Information processing
Language
Linguistics
Medicine
Membrane Proteins - genetics
Membrane Proteins - physiology
Mutation
Natural language processing
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neurosciences
NMR
Nuclear magnetic resonance
Proteins
Reading comprehension
Reference Values
Semantics
Skills
Social and Behavioral Sciences
Studies
Young Adult
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Title CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs
URI https://www.ncbi.nlm.nih.gov/pubmed/23115634
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http://dx.doi.org/10.1371/journal.pone.0046995
Volume 7
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