Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

• Published in: PloS one Vol. 13; no. 9; p. e0202436
• Main Authors: McAnally, Danielle, Siddiquee, Khandaker, Gomaa, Ahmed, Szabo, Andras, Vasile, Stefan, Maloney, Patrick R, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Morfa, Camilo J, Hershberger, Paul, Falter, Rebecca, Williamson, Robert, Terry, David B, Farjo, Rafal, Pinkerton, Anthony B, Qi, Xiaping, Quigley, Judith, Boulton, Michael E, Grant, Maria B, Smith, Layton H
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2018; Public Library of Science (PLoS)
• Subjects: Age; Aminoquinolines; Aminoquinolines - chemistry; Aminoquinolines - pharmacokinetics; Aminoquinolines - therapeutic use; Amodiaquine; Angiogenesis; Angiogenesis inhibitors; Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - pharmacology; Angiogenesis Inhibitors - therapeutic use; Animals; Antagonists; Antimalarials - chemistry; Antimalarials - pharmacokinetics; Antimalarials - therapeutic use; Apelin - metabolism; Apelin Receptors - antagonists & inhibitors; Apelin Receptors - metabolism; Biology and Life Sciences; Cell Line; Cell Proliferation - drug effects; Choroidal Neovascularization - drug therapy; Choroidal Neovascularization - pathology; Complications and side effects; Creationism; Cytokines; Development and progression; Diabetes; Diabetes mellitus; Diabetic retinopathy; Disease Models, Animal; Dosage and administration; Drug development; Drug Repositioning; Drug therapy; Eye; Eye diseases; Female; Genomics; Growth factors; Health aspects; Health care; Humans; Lasers; Macular degeneration; Malaria; Medicine; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Neovascularization; Obesity; Organic chemistry; Patients; Pharmacology; Prevention; Proteins; Quality of life; Quinolines; Research and Analysis Methods; Retina; Retinal Neovascularization - drug therapy; Retinal Neovascularization - pathology; Retinopathy; Risk factors; Small Molecule Libraries - chemistry; Small Molecule Libraries - therapeutic use; Therapeutic applications; Tissue Distribution; Toxicity; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascularization; Vision disorders; Visual impairment; Indiana; Florida; Alabama; United States > US; Oklahoma; Indianapolis Indiana

Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases significantly impacts the productivity and quality of life of pati...