Human leukocyte antigen and demographic characteristics in Chinese patients with active peripheral type psoriatic arthritis who had inadequate response to conventional disease-modifying antirheumatic drugs in a single dermatologic clinic

• Published in: PloS one Vol. 14; no. 1; p. e0210076
• Main Authors: Sin, Chi-Zai, Wang, Ting-Shun, Chiu, Hsien-Yi, Tsai, Tsen-Fang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.01.2019; Public Library of Science (PLoS)
• Subjects: Adult; Alleles; Antigens; Antirheumatic agents; Antirheumatic Agents - therapeutic use; Arthritis; Arthritis, Psoriatic - drug therapy; Arthritis, Psoriatic - ethnology; Arthritis, Psoriatic - genetics; Asian Continental Ancestry Group - genetics; Biological treatment; Biology and Life Sciences; Cases (containers); Demographics; Dermatology; Drb1 protein; Drugs; Female; Gene Frequency; Genetic polymorphisms; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genotype; Genotyping; Haplotypes; Histocompatibility antigen HLA; HLA Antigens - genetics; Hospitals; Humans; Joint diseases; Leukocytes; Male; Medicine; Medicine and Health Sciences; Middle Aged; Nonsteroidal anti-inflammatory drugs; Patients; People and Places; Polymorphism; Polymorphism, Genetic; Population; Population genetics; Population studies; Psoriasis; Psoriasis - drug therapy; Psoriasis - ethnology; Psoriasis - genetics; Psoriatic arthritis; Research and Analysis Methods; Rheumatology; Risk factors; Skin - drug effects; Skin - metabolism; Skin - pathology; Skin diseases; Studies; Taiwan; Taiwan; China; Asia

Correlation between severity of psoriasis and psoriatic arthritis (PsA) is inconsistent. Also, human leukocyte antigen (HLA)-Cw6 was found to be underrepresented in severe psoriasis who failed conventional systemic therapies, but the effect of HLA polymorphism on PsA severity needs to be confirmed....