Safety and preliminary efficacy of orally administered lyophilized fecal microbiota product compared with frozen product given by enema for recurrent Clostridium difficile infection: A randomized clinical trial

• Published in: PloS one Vol. 13; no. 11; p. e0205064
• Main Authors: Jiang, Zhi-Dong, Jenq, Robert R., Ajami, Nadim J., Petrosino, Joseph F., Alexander, Ashley A., Ke, Shi, Iqbal, Tehseen, DuPont, Andrew W., Muldrew, Kenneth, Shi, Yushu, Peterson, Christine, Do, Kim-Anh, DuPont, Herbert L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.11.2018; Public Library of Science (PLoS)
• Subjects: Administration, Oral; Adult; Adults; Aged; Aged, 80 and over; Analysis; Antibiotics; Bacteria; Biology and Life Sciences; Cancer; Capsules; Care and treatment; Clinical trials; Clostridium difficile - isolation & purification; Clostridium infections; Clostridium Infections - therapy; Colon; Colonoscopy; Comparative analysis; Cryopreservation; Effectiveness; Enema; Enema - adverse effects; Enema - methods; Epidemiology; Fecal Microbiota Transplantation - adverse effects; Fecal Microbiota Transplantation - methods; Fecal microflora; Feces; Female; Freeze Drying; Health care; Humans; Infections; Infectious diseases; Male; Medicine and Health Sciences; Microbiomes; Microbiota; Middle Aged; Oral administration; Pathogens; Product safety; Public health; Rectum; Recurrent infection; Safety; Spore-forming bacteria; Transplantation; Transplants & implants; Treatment outcome; Virology; Young Adult; United States > US

Fecal microbiota transplantation (FMT) via colonoscopy or enema has become a commonly used treatment of recurrent C. difficile infection (CDI). To compare the safety and preliminary efficacy of orally administered lyophilized microbiota product compared with frozen product by enema. In a single cent...