Fiber type-specific afferent nerve activity induced by transient contractions of rat bladder smooth muscle in pathological states

• Published in: PloS one Vol. 12; no. 12; p. e0189941
• Main Authors: Kuga, Nahoko, Tanioka, Asao, Hagihara, Koichiro, Kawai, Tomoyuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.12.2017; Public Library of Science (PLoS)
• Subjects: Afferent Pathways - drug effects; Analysis; Animal models; Animal research models; Animals; Biology and Life Sciences; Bladder; Body temperature; Catheters; Contraction; Cyclophosphamide; Cyclophosphamide - pharmacology; Female; Fibers; Inflammation; Laboratory animals; Medicine and Health Sciences; Muscle contraction; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - pathology; Muscles; Nerves; Neurosciences; Pharmaceutical industry; Pharmacology; Physiological aspects; Physiology; Pressure; Prostaglandin E2; Rats; Rats, Sprague-Dawley; Research and Analysis Methods; Respiration; Rodents; Sensory neurons; Sensory receptors; Smooth muscle; Urinary bladder; Urinary Bladder - drug effects; Urinary Bladder - pathology; Urology; Japan

Bladder smooth muscle shows spontaneous phasic contractions, which undergo a variety of abnormal changes depending on pathological conditions. How abnormal contractions affect the activity of bladder afferent nerves remains to be fully tested. In this study, we examined the relationship between tran...