A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus

• Published in: PloS one Vol. 14; no. 12; p. e0225651
• Main Authors: Li, Yupeng, Higgs, Richard E., Hoffman, Robert W., Dow, Ernst R., Liu, Xiong, Petri, Michelle, Wallace, Daniel J., Dörner, Thomas, Eastwood, Brian J., Miller, Bradley B., Liu, Yushi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.12.2019; Public Library of Science (PLoS)
• Subjects: Abnormalities; Adaptive immunity; Algorithms; Analysis; Autoimmune diseases; Bayes Theorem; Bayesian analysis; Biology and Life Sciences; Biomarkers; Cancer; Chronic conditions; Clinical trials; Clinical Trials, Phase III as Topic; Computer and Information Sciences; Computer Simulation; Data Mining; Datasets as Topic; Drug therapy; Endoplasmic reticulum; Gene expression; Gene Expression Profiling; Gene loci; Gene Regulatory Networks - immunology; Genes; Genomics; Humans; Immune response; Inflammatory diseases; Interferon regulatory factor 1; Interferon regulatory factor 7; Janus kinase 2; Janus Kinase 2 - immunology; Janus Kinase 2 - metabolism; Linear Models; Lupus; Lupus erythematosus; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Medicine and Health Sciences; Methods; Models, Genetic; Natural language processing; Network topologies; Oligonucleotide Array Sequence Analysis; Organs; Pathogenesis; Pharmaceutical industry; Random variables; Randomized Controlled Trials as Topic; Ribonucleic acid; RNA; Signal Transduction - drug effects; Signal Transduction - genetics; Signal Transduction - immunology; Social networks; Stat1 protein; STAT1 Transcription Factor - immunology; STAT1 Transcription Factor - metabolism; Stat2 protein; STAT2 Transcription Factor - immunology; STAT2 Transcription Factor - metabolism; Success; Systemic lupus erythematosus; Therapeutic applications; United States; Los Angeles California; California; United States > US; Indianapolis Indiana

Systemic lupus erythematosus (SLE) is a chronic, remitting, and relapsing, inflammatory disease involving multiple organs, which exhibits abnormalities of both the innate and adaptive immune responses. A limited number of transcriptomic studies have characterized the gene pathways involved in SLE in...