Intensive care treatments associated with favorable discharge outcomes in Argentine children with severe traumatic brain injury: For the South American Guideline Adherence Group
Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. We conducted a secondary...
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| Published in | PloS one Vol. 12; no. 12; p. e0189296 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
15.12.2017
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI.
We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality.
Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]).
There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. |
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| AbstractList | Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS [greater than or equal to] 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality. Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]). There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. Objective Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. Methods We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality. Results Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]). Conclusion There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. Objective Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. Methods We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS [greater than or equal to] 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality. Results Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]). Conclusion There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality. Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]). There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. OBJECTIVELittle is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI.METHODSWe conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality.RESULTSOf the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]).CONCLUSIONThere is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. Objective Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI. Methods We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality. Results Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]). Conclusion There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify indicators of intensive care unit (ICU) treatments associated with favorable outcomes in Argentine children with severe TBI.We conducted a secondary analysis of data from patients previously enrolled in a prospective seven center study of children with severe TBI who were admitted to an ICU in one of the seven study centers. Severe TBI was defined by head AIS ≥ 3, head CT with traumatic lesion, and admission GCS < 9. Seven indicators of best practice TBI care were examined. The primary outcome was discharge Pediatric Cerebral Performance Category Scale [PCPC] and Pediatric Overall Performance category Scale [POPC]. We also examined variation in ICU care and in-patient mortality.Of the 117 children, 67% were male and 7.5 (4.3) years on average, 92% had isolated TBI. Hypotension (54%) was more common than hypoxia (28%) and clinical or radiographic signs of high intracranial pressure (ICP) were observed in 92%. Yet, ICP monitoring occurred in 60% and hyperosmolar therapy was used in only 36%. Adherence to indicators of best TBI practice ranged from 55.6% to 83.7% across the seven centers and adherence was associated with favorable discharge PCPC (aRR 0.98; 95% CI [0.96, 0.99]), and POPC (aRR 0.98; 95% CI [0.96, 0.99]). Compared to patients whose adherence rates were below 65%, patients whose adherence rates were higher between 75%-100% had better discharge PCPC (aRR 0.28; 95% CI [0.10, 0.83]) and POPC (aRR 0.32; 95% CI [0.15, 0.73]. Two indicators were associated with favorable discharge PCPC: Avoidance of hypoxia (aRR 0.46; 95% CI [0.23, 0.93]), and Nutrition started in 72 hours (aRR 0.45; 95% CI [0.21, 0.99]). Avoiding hypoxia was also associated with favorable discharge POPC (aRR 0.47; 95% CI [0.22, 0.99]).There is variation in Argentine ICU practice in the care of children with severe TBI. Second insults are common and hyperosmolar therapy use is uncommon. Adherence to best practice TBI care by avoiding hypoxia and providing timely nutrition were associated with significantly favorable discharge outcomes. Implementing strategies that prevent hypoxia and facilitate early nutrition in the ICUs are urgently needed to improve pediatric TBI outcomes. |
| Audience | Academic |
| Author | Petroni, Gustavo J Farr, Carly K Bell, Michael J González Carrillo, Osvaldo R Vanella, Elida E Ballarini, Nicolás M Qiu, Qian Guadagnoli, Nahuel Sáenz, Silvia S Medici, Paula L Lujan, Silvia B Depetris, María Alejandra Vavilala, Monica S Faguaga, Gabriela A García, Mirta E Busso, Leonardo O Baggio, Gloria M |
| AuthorAffiliation | 9 Hospital Interzonal Especializado Materno Infantil Dr. Vitorio Tetamanti, Mar del Plata, Buenos Aires, Argentina Public Library of Science, FRANCE 3 Hospital de emergencias Dr. Clemente Álvarez, Rosario, Santa Fe, Argentina 7 Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires, Argentina 11 Hospital Pediátrico Dr. Humberto Notti, Mendoza, Mendoza, Argentina 2 Centro de Informática e Investigación Clínica, Rosario, Santa Fe, Argentina 8 Hospital de Niños Dr. Orlando Alassia, Santa Fe, Santa Fe, Argentina 4 Pediatrics, Critical Care Medicine, Children’s National Hospital, Washington D.C., United States of America 5 Hospital de Niños Víctor J Vilela, Rosario, Santa Fe, Argentina 1 Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, United States of America 6 Hospital El Cruce. Ezpeleta Oeste, Buenos Aires, Argentina 10 Hospital de Niños de la Santísima Trinidad, Córdoba, Cordoba, Argentina |
| AuthorAffiliation_xml | – name: 10 Hospital de Niños de la Santísima Trinidad, Córdoba, Cordoba, Argentina – name: Public Library of Science, FRANCE – name: 2 Centro de Informática e Investigación Clínica, Rosario, Santa Fe, Argentina – name: 4 Pediatrics, Critical Care Medicine, Children’s National Hospital, Washington D.C., United States of America – name: 5 Hospital de Niños Víctor J Vilela, Rosario, Santa Fe, Argentina – name: 6 Hospital El Cruce. Ezpeleta Oeste, Buenos Aires, Argentina – name: 3 Hospital de emergencias Dr. Clemente Álvarez, Rosario, Santa Fe, Argentina – name: 11 Hospital Pediátrico Dr. Humberto Notti, Mendoza, Mendoza, Argentina – name: 7 Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires, Argentina – name: 8 Hospital de Niños Dr. Orlando Alassia, Santa Fe, Santa Fe, Argentina – name: 9 Hospital Interzonal Especializado Materno Infantil Dr. Vitorio Tetamanti, Mar del Plata, Buenos Aires, Argentina – name: 1 Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, United States of America |
| Author_xml | – sequence: 1 givenname: Monica S surname: Vavilala fullname: Vavilala, Monica S organization: Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, United States of America – sequence: 2 givenname: Silvia B surname: Lujan fullname: Lujan, Silvia B organization: Hospital de emergencias Dr. Clemente Álvarez, Rosario, Santa Fe, Argentina – sequence: 3 givenname: Qian surname: Qiu fullname: Qiu, Qian organization: Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, United States of America – sequence: 4 givenname: Michael J surname: Bell fullname: Bell, Michael J organization: Pediatrics, Critical Care Medicine, Children's National Hospital, Washington D.C., United States of America – sequence: 5 givenname: Nicolás M orcidid: 0000-0002-3432-8931 surname: Ballarini fullname: Ballarini, Nicolás M organization: Centro de Informática e Investigación Clínica, Rosario, Santa Fe, Argentina – sequence: 6 givenname: Nahuel surname: Guadagnoli fullname: Guadagnoli, Nahuel organization: Centro de Informática e Investigación Clínica, Rosario, Santa Fe, Argentina – sequence: 7 givenname: María Alejandra orcidid: 0000-0002-8063-6601 surname: Depetris fullname: Depetris, María Alejandra organization: Centro de Informática e Investigación Clínica, Rosario, Santa Fe, Argentina – sequence: 8 givenname: Gabriela A surname: Faguaga fullname: Faguaga, Gabriela A organization: Hospital de Niños Víctor J Vilela, Rosario, Santa Fe, Argentina – sequence: 9 givenname: Gloria M surname: Baggio fullname: Baggio, Gloria M organization: Hospital de Niños Víctor J Vilela, Rosario, Santa Fe, Argentina – sequence: 10 givenname: Leonardo O surname: Busso fullname: Busso, Leonardo O organization: Hospital El Cruce. Ezpeleta Oeste, Buenos Aires, Argentina – sequence: 11 givenname: Mirta E surname: García fullname: García, Mirta E organization: Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires, Argentina – sequence: 12 givenname: Osvaldo R surname: González Carrillo fullname: González Carrillo, Osvaldo R organization: Hospital de Niños Dr. Orlando Alassia, Santa Fe, Santa Fe, Argentina – sequence: 13 givenname: Paula L surname: Medici fullname: Medici, Paula L organization: Hospital Interzonal Especializado Materno Infantil Dr. Vitorio Tetamanti, Mar del Plata, Buenos Aires, Argentina – sequence: 14 givenname: Silvia S surname: Sáenz fullname: Sáenz, Silvia S organization: Hospital de Niños de la Santísima Trinidad, Córdoba, Cordoba, Argentina – sequence: 15 givenname: Elida E surname: Vanella fullname: Vanella, Elida E organization: Hospital Pediátrico Dr. Humberto Notti, Mendoza, Mendoza, Argentina – sequence: 16 givenname: Carly K orcidid: 0000-0003-2267-8181 surname: Farr fullname: Farr, Carly K organization: Anesthesiology and Pain Medicine, Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, United States of America – sequence: 17 givenname: Gustavo J surname: Petroni fullname: Petroni, Gustavo J organization: Hospital de emergencias Dr. Clemente Álvarez, Rosario, Santa Fe, Argentina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29244842$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00381_020_04603_9 crossref_primary_10_1016_j_jpedsurg_2019_06_022 crossref_primary_10_3390_brainsci12081009 crossref_primary_10_3390_tomography9020044 crossref_primary_10_1371_journal_pone_0275255 crossref_primary_10_1016_j_jss_2021_03_024 crossref_primary_10_3389_fneur_2018_01097 crossref_primary_10_1155_2020_1965231 |
| Cites_doi | 10.1097/PCC.0000000000000772 10.1111/pan.12415 10.1097/PCC.0000000000000698 10.1089/neu.2007.0491 10.1136/jnnp.2006.099796 10.1097/CCM.0000000000000507 10.1097/TA.0b013e3181ce1eed 10.1097/TA.0b013e3181ad32c7 10.1056/NEJMoa1207363 10.1371/journal.pone.0166478 10.1371/journal.pone.0118061 10.1371/journal.pone.0094942 10.1097/00001199-200507000-00008 10.1001/jamapediatrics.2013.5316 10.1097/00003246-200007000-00072 10.1097/01.TA.0000101759.23607.57 10.4103/2229-5151.79279 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Vavilala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Vavilala et al 2017 Vavilala et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Vavilala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Vavilala et al 2017 Vavilala et al |
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| DOI | 10.1371/journal.pone.0189296 |
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| References | P Curry (ref9) 2011; 1 MS Vavilala (ref15) 2016; 11 G Petroni (ref16) 2010; 68 N Hardcastle (ref7) 2014; 24 ref20 MS Vavilala (ref12) 2014; 42 V Nenadovic (ref18) 2014; 9 S Marino (ref6) 2007; 78 DH Fiser (ref17) 2000; 28 RM Chesnut (ref21) 2012; 367 S Philip (ref8) 2009; 67 MS Vavilala (ref10) 2003; 55 C Rondina (ref3) 2005; 20 MM Pollack (ref19) 2014; 168 MC Dewan (ref1) 2016; 91 UB,IV Samant (ref11) 2008; 25 PM Kochanek (ref13) 2012; 13 NA Carney (ref2) 2016; 17 (ref4) 2016 H Doshi (ref5) 2015; 10 JM Graves (ref14) 2016; 17 |
| References_xml | – volume: 17 start-page: 658 issue: 7 year: 2016 ident: ref2 article-title: Postdischarge Care of Pediatric Traumatic Brain Injury in Argentina: A Multicenter Randomized Controlled Trial publication-title: Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies doi: 10.1097/PCC.0000000000000772 contributor: fullname: NA Carney – volume: 24 start-page: 703 issue: 7 year: 2014 ident: ref7 article-title: Update on the 2012 guidelines for the management of pediatric traumatic brain injury–information for the anesthesiologist publication-title: Pediatric Anesthesia doi: 10.1111/pan.12415 contributor: fullname: N Hardcastle – volume: 17 start-page: 438 issue: 5 year: 2016 ident: ref14 article-title: Guideline Adherence and Hospital Costs in Pediatric Severe Traumatic Brain Injury publication-title: Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies doi: 10.1097/PCC.0000000000000698 contributor: fullname: JM Graves – volume: 25 start-page: 495 issue: 5 year: 2008 ident: ref11 article-title: Time of hypotension and discharge outcome in children with severe traumatic brain injury publication-title: J Neurotrauma doi: 10.1089/neu.2007.0491 contributor: fullname: UB,IV Samant – volume: 13 start-page: S1 issue: Suppl 1 year: 2012 ident: ref13 article-title: Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents—second edition publication-title: Pediatric Crit Care Med contributor: fullname: PM Kochanek – ident: ref20 – year: 2016 ident: ref4 article-title: Vital Statistics 2015 – volume: 78 start-page: 501 issue: 5 year: 2007 ident: ref6 article-title: Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2006.099796 contributor: fullname: S Marino – volume: 42 start-page: 2258 issue: 10 year: 2014 ident: ref12 article-title: Pediatric guideline adherence and outcomes study. Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury publication-title: Crit Care Med doi: 10.1097/CCM.0000000000000507 contributor: fullname: MS Vavilala – volume: 68 start-page: 564 issue: 3 year: 2010 ident: ref16 article-title: Early prognosis of severe traumatic brain injury in an urban argentinian trauma center publication-title: J Trauma doi: 10.1097/TA.0b013e3181ce1eed contributor: fullname: G Petroni – volume: 67 start-page: S128 issue: 2 year: 2009 ident: ref8 article-title: Cerebrovascular pathophysiology in pediatric traumatic brain injury publication-title: J Trauma doi: 10.1097/TA.0b013e3181ad32c7 contributor: fullname: S Philip – volume: 367 start-page: 2471 issue: 26 year: 2012 ident: ref21 article-title: A trial of intracranial-pressure monitoring in traumatic brain injury publication-title: N Engl J Med doi: 10.1056/NEJMoa1207363 contributor: fullname: RM Chesnut – volume: 11 start-page: e0166478 issue: 12 year: 2016 ident: ref15 article-title: Benchmarking prehospital and emergency department care for argentine children with traumatic brain injury: For the south american guideline adherence group.(research article)(report) publication-title: PLoS ONE doi: 10.1371/journal.pone.0166478 contributor: fullname: MS Vavilala – volume: 91 start-page: 509.e1 year: 2016 ident: ref1 article-title: Epidemiology of Global Pediatric Traumatic Brain Injury publication-title: Qualitative Review. World Neurosurgery contributor: fullname: MC Dewan – volume: 10 issue: 2 year: 2015 ident: ref5 article-title: Cerebral hemodynamic changes of mild traumatic brain injury at the acute stage publication-title: PLoS ONE doi: 10.1371/journal.pone.0118061 contributor: fullname: H Doshi – volume: 9 start-page: e94942 issue: 4 year: 2014 ident: ref18 article-title: Phase Synchronization in Electroencephalographic Recordings Prognosticates Outcome in Paediatric Coma publication-title: PLOS ONE doi: 10.1371/journal.pone.0094942 contributor: fullname: V Nenadovic – volume: 20 start-page: 368 issue: 4 year: 2005 ident: ref3 article-title: Mortality and morbidity from moderate to severe traumatic brain injury in Argentina.(Focus on Clinical Practice and Research) publication-title: J Head Trauma Rehabil doi: 10.1097/00001199-200507000-00008 contributor: fullname: C Rondina – volume: 168 start-page: 671 issue: 7 year: 2014 ident: ref19 article-title: Relationship between the functional status scale and the pediatric overall performance category and pediatric cerebral performance category scales publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2013.5316 contributor: fullname: MM Pollack – volume: 28 start-page: 2616 issue: 7 year: 2000 ident: ref17 article-title: Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments publication-title: Crit Care Med doi: 10.1097/00003246-200007000-00072 contributor: fullname: DH Fiser – volume: 55 start-page: 1039 issue: 6 year: 2003 ident: ref10 article-title: Blood pressure and outcome after severe pediatric traumatic brain injury publication-title: J Trauma doi: 10.1097/01.TA.0000101759.23607.57 contributor: fullname: MS Vavilala – volume: 1 start-page: 27 issue: 1 year: 2011 ident: ref9 article-title: Perioperative management of traumatic brain injury publication-title: International Journal of Critical Illness and Injury Science doi: 10.4103/2229-5151.79279 contributor: fullname: P Curry |
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| Snippet | Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify... Objective Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify... OBJECTIVELittle is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify... Objective Little is known about the critical care management of children with traumatic brain injury (TBI) in low middle income countries. We aimed to identify... |
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| SubjectTerms | Adhesion Analysis Anesthesiology Best practice Biology and Life Sciences Brain Brain injuries Brain research Care and treatment CAT scans Children Critical care Data processing Diagnosis Discharge Emergency medical care Head injuries Health aspects Hospital costs Hypotension Hypoxia Indicators Injury prevention Intensive care Intensive care units Intracranial pressure Medical prognosis Medicine Medicine and Health Sciences Nutrition Osmotic pressure Pain Patients Pediatrics Physical Sciences Secondary analysis Surgeons Therapy Trauma Traumatic brain injury |
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| Title | Intensive care treatments associated with favorable discharge outcomes in Argentine children with severe traumatic brain injury: For the South American Guideline Adherence Group |
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