Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study

• Published in: PloS one Vol. 12; no. 10; p. e0186218
• Main Authors: Robiou-du-Pont, Sébastien, Anand, Sonia S, Morrison, Katherine M, McDonald, Sarah D, Atkinson, Stephanie A, Teo, Koon K, Meyre, David
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.10.2017; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Arteriosclerosis; Atherosclerosis; Biology and Life Sciences; Blood; Blood pressure; Blood Pressure - genetics; Cardiovascular disease; Child, Preschool; Children; Children & youth; Epigenetics; Families & family life; Family studies; Female; Genealogy; Genetic aspects; Genetic effects; Genetic Markers; Genome-wide association studies; Genome-Wide Association Study; Genomes; Health sciences; Humans; Hypertension; Hypertension - genetics; Hypertension - physiopathology; Infant; Kinases; Loci; Male; Medical research; Medicine and Health Sciences; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Mothers; Multiple births; Obesity; Offspring; Pediatrics; Physiological aspects; Polymorphism, Single Nucleotide; Proteins; Puberty; Research methodology; Risk Factors; Single-nucleotide polymorphism; Social Sciences; src-Family Kinases - genetics; Steroid 17-alpha-Hydroxylase - genetics; Studies; Teenagers; Canada; Ontario Canada

Previous genome wide association studies (GWAS) identified associations of multiple common variants with diastolic and systolic blood pressure traits in adults. However, the contribution of these loci to variations of blood pressure in early life is unclear. We assessed the child and parental contri...