Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study

• Published in: PloS one Vol. 15; no. 12; p. e0238552
• Main Authors: Monteiro, Ana C, Suri, Rajat, Emeruwa, Iheanacho O, Stretch, Robert J, Cortes-Lopez, Roxana Y, Sherman, Alexander, Lindsay, Catherine C, Fulcher, Jennifer A, Goodman-Meza, David, Sapru, Anil, Buhr, Russell G, Chang, Steven Y, Wang, Tisha, Qadir, Nida
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.12.2020; Public Library of Science (PLoS)
• Subjects: Aged; Anticoagulants; Artificial respiration; Biology and Life Sciences; C-Reactive Protein; Cell number; Clinical trials; Cohort analysis; Cohort Studies; Complications and side effects; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - complications; COVID-19 - epidemiology; COVID-19 - virology; Critical care; Electronic health records; Electronic medical records; Female; Ferritin; Ferritins - blood; Health aspects; Health risks; Hospital Mortality; Hospital systems; Hospitals; Humans; Infectious diseases; Inflammation; Intensive Care Units; Interleukin 6; Interleukin-6 - blood; Intubation; L-Lactate Dehydrogenase - blood; Lymphocyte Count; Lymphocytes; Male; Markers; Mechanical properties; Mechanical ventilation; Medicine; Medicine and Health Sciences; Methods; Middle Aged; Mortality; Obesity; Obesity - blood; Obesity - complications; Obesity - epidemiology; Obesity - virology; Observational studies; Patients; Procalcitonin; Procalcitonin - blood; Regression analysis; Respiration, Artificial; Respiratory distress syndrome; Respiratory failure; Respiratory Insufficiency - blood; Respiratory Insufficiency - complications; Respiratory Insufficiency - epidemiology; Respiratory Insufficiency - virology; Retrospective Studies; Risk analysis; Risk Factors; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Smoking; Smoking - adverse effects; Ventilation; Ventilators; United States; Los Angeles California; United States > US

To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical ventilation (IMV). A retrospective, observational cohort study of 112 inpatient adults diagnosed with COVID-19 between March 12 and April 16, 2020. Data were manually extract...