RHPS4 G-Quadruplex Ligand Induces Anti-Proliferative Effects in Brain Tumor Cells

• Published in: PloS one Vol. 9; no. 1; p. e86187
• Main Authors: Lagah, Sunil, Tan, I-Li, Radhakrishnan, Priya, Hirst, Robert A., Ward, Jennifer H., O’Callaghan, Chris, Smith, Stuart J., Stevens, Malcolm F. G., Grundy, Richard G., Rahman, Ruman
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.01.2014; Public Library of Science (PLoS)
• Subjects: Acridines - chemistry; Acridines - pharmacology; Animals; Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antiproliferatives; Biology; Brain; Brain cancer; Brain Neoplasms; Brain research; Brain tumors; c-Myc protein; Cancer; Cell cycle; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Central nervous system; Cilia - drug effects; Cilia - physiology; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; DNA structure; Drug Screening Assays, Antitumor; Endothelial cells; Endothelial Cells - drug effects; Ependyma - pathology; G-Quadruplexes; Glioblastoma; Glioblastoma cells; Glioma cells; Gliomas; Humans; Immunotherapy; In vivo methods and tests; Inhibitory Concentration 50; Ligands; Medical research; Medicine; Medulloblastoma; Melanoma; Myc protein; Nervous system; Pediatrics; Proteins; Proto-Oncogene Proteins c-myc - metabolism; Rats; Taq Polymerase - antagonists & inhibitors; Telomerase; Telomerase - antagonists & inhibitors; Telomerase - chemistry; Telomere Homeostasis - drug effects; Telomeres; Toxicity; Tumor cells; United Kingdom > UK

Telomeric 3' overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt telomeric s...