Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4
Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltran...
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Published in | PloS one Vol. 10; no. 4; p. e0124301 |
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14.04.2015
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Abstract | Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one or a combination of the following reagents: L-methionine as a methyl donor, valproic acid as a pan-Hdac inhibitor, and folic acid and vitamin B12 as putative factors involved in age-related hearing loss. The mice were treated from ages 4 to 12 weeks (N ≥ 5), and auditory brainstem response (ABR) thresholds were measured at 8, 16, and 32 kHz. Treatment of the mice with a combination of L-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz. Treatment with any of these reagents individually produced no such effect. Microarray analyses detected 299 gene probes that were significantly up- or down-regulated in the cochleae of mice treated with M+V compared with the control vehicle-treated mice. Quantitative RT-PCR confirmed significant up-regulation of a zinc importer gene, Zip4, in the cochleae of mice treated with M+V. Immunohistochemistry demonstrated an intense Zip4 signal in cochlear tissues such as the lateral wall, organ of Corti, and spiral ganglion. Finally, mice treated with the Zip4 inducer (-)-epigallocatechin-3-O-gallate showed a significant reduction in the increase of the ABR threshold at 32 kHz and up-regulation of Zip4 expression in the cochlea. This study suggests that epigenetic regulatory pathways can modify auditory function and that zinc intake in the cochlea via Zip4 mediates maintenance of mammalian hearing. |
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AbstractList | Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one or a combination of the following reagents: L-methionine as a methyl donor, valproic acid as a pan-Hdac inhibitor, and folic acid and vitamin B12 as putative factors involved in age-related hearing loss. The mice were treated from ages 4 to 12 weeks (N ≥ 5), and auditory brainstem response (ABR) thresholds were measured at 8, 16, and 32 kHz. Treatment of the mice with a combination of L-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz. Treatment with any of these reagents individually produced no such effect. Microarray analyses detected 299 gene probes that were significantly up- or down-regulated in the cochleae of mice treated with M+V compared with the control vehicle-treated mice. Quantitative RT-PCR confirmed significant up-regulation of a zinc importer gene, Zip4, in the cochleae of mice treated with M+V. Immunohistochemistry demonstrated an intense Zip4 signal in cochlear tissues such as the lateral wall, organ of Corti, and spiral ganglion. Finally, mice treated with the Zip4 inducer (–)-epigallocatechin-3-O-gallate showed a significant reduction in the increase of the ABR threshold at 32 kHz and up-regulation of Zip4 expression in the cochlea. This study suggests that epigenetic regulatory pathways can modify auditory function and that zinc intake in the cochlea via Zip4 mediates maintenance of mammalian hearing. Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one or a combination of the following reagents: L-methionine as a methyl donor, valproic acid as a pan-Hdac inhibitor, and folic acid and vitamin B12 as putative factors involved in age-related hearing loss. The mice were treated from ages 4 to 12 weeks (N [greater than or equal to] 5), and auditory brainstem response (ABR) thresholds were measured at 8, 16, and 32 kHz. Treatment of the mice with a combination of L-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz. Treatment with any of these reagents individually produced no such effect. Microarray analyses detected 299 gene probes that were significantly up- or down-regulated in the cochleae of mice treated with M+V compared with the control vehicle-treated mice. Quantitative RT-PCR confirmed significant up-regulation of a zinc importer gene, Zip4, in the cochleae of mice treated with M+V. Immunohistochemistry demonstrated an intense Zip4 signal in cochlear tissues such as the lateral wall, organ of Corti, and spiral ganglion. Finally, mice treated with the Zip4 inducer (-)-epigallocatechin-3-O-gallate showed a significant reduction in the increase of the ABR threshold at 32 kHz and up-regulation of Zip4 expression in the cochlea. This study suggests that epigenetic regulatory pathways can modify auditory function and that zinc intake in the cochlea via Zip4 mediates maintenance of mammalian hearing. Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one or a combination of the following reagents: L-methionine as a methyl donor, valproic acid as a pan-Hdac inhibitor, and folic acid and vitamin B12 as putative factors involved in age-related hearing loss. The mice were treated from ages 4 to 12 weeks (N ≥ 5), and auditory brainstem response (ABR) thresholds were measured at 8, 16, and 32 kHz. Treatment of the mice with a combination of L-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz. Treatment with any of these reagents individually produced no such effect. Microarray analyses detected 299 gene probes that were significantly up- or down-regulated in the cochleae of mice treated with M+V compared with the control vehicle-treated mice. Quantitative RT-PCR confirmed significant up-regulation of a zinc importer gene, Zip4 , in the cochleae of mice treated with M+V. Immunohistochemistry demonstrated an intense Zip4 signal in cochlear tissues such as the lateral wall, organ of Corti, and spiral ganglion. Finally, mice treated with the Zip4 inducer (–)-epigallocatechin-3- O -gallate showed a significant reduction in the increase of the ABR threshold at 32 kHz and up-regulation of Zip4 expression in the cochlea. This study suggests that epigenetic regulatory pathways can modify auditory function and that zinc intake in the cochlea via Zip4 mediates maintenance of mammalian hearing. Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one or a combination of the following reagents: <smallcaps>L</smallcaps>-methionine as a methyl donor, valproic acid as a pan-Hdac inhibitor, and folic acid and vitamin B12 as putative factors involved in age-related hearing loss. The mice were treated from ages 4 to 12 weeks (N ≥ 5), and auditory brainstem response (ABR) thresholds were measured at 8, 16, and 32 kHz. Treatment of the mice with a combination of <smallcaps>L</smallcaps>-methionine and valproic acid (M+V) significantly reduced the increase in the ABR threshold at 32 kHz. Treatment with any of these reagents individually produced no such effect. Microarray analyses detected 299 gene probes that were significantly up- or down-regulated in the cochleae of mice treated with M+V compared with the control vehicle-treated mice. Quantitative RT-PCR confirmed significant up-regulation of a zinc importer gene, Zip4, in the cochleae of mice treated with M+V. Immunohistochemistry demonstrated an intense Zip4 signal in cochlear tissues such as the lateral wall, organ of Corti, and spiral ganglion. Finally, mice treated with the Zip4 inducer (-)-epigallocatechin-3-O-gallate showed a significant reduction in the increase of the ABR threshold at 32 kHz and up-regulation of Zip4 expression in the cochlea. This study suggests that epigenetic regulatory pathways can modify auditory function and that zinc intake in the cochlea via Zip4 mediates maintenance of mammalian hearing. |
Audience | Academic |
Author | Fujii, Masato Miya, Fuyuki Tsunoda, Tatsuhiko Matsunaga, Tatsuo Mutai, Hideki |
AuthorAffiliation | 3 Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan Universitat Pompeu Fabra, SPAIN 1 Laboratory of Auditory Disorders, Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan 2 Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan |
AuthorAffiliation_xml | – name: 1 Laboratory of Auditory Disorders, Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan – name: Universitat Pompeu Fabra, SPAIN – name: 3 Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan – name: 2 Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan |
Author_xml | – sequence: 1 givenname: Hideki surname: Mutai fullname: Mutai, Hideki organization: Laboratory of Auditory Disorders, Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan – sequence: 2 givenname: Fuyuki surname: Miya fullname: Miya, Fuyuki organization: Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan – sequence: 3 givenname: Masato surname: Fujii fullname: Fujii, Masato organization: Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan – sequence: 4 givenname: Tatsuhiko surname: Tsunoda fullname: Tsunoda, Tatsuhiko organization: Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan – sequence: 5 givenname: Tatsuo surname: Matsunaga fullname: Matsunaga, Tatsuo organization: Laboratory of Auditory Disorders, Division of Balance and Hearing Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan |
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CitedBy_id | crossref_primary_10_1038_srep25056 crossref_primary_10_1016_j_bbrc_2018_08_032 crossref_primary_10_1042_EBC20160073 crossref_primary_10_1038_s41598_024_52629_9 crossref_primary_10_1016_j_jnutbio_2019_108247 crossref_primary_10_1007_s00441_016_2401_2 crossref_primary_10_1038_s10038_018_0507_y crossref_primary_10_1016_j_gene_2020_144677 crossref_primary_10_1016_j_gdata_2015_06_022 |
Cites_doi | 10.1016/j.amjoto.2014.11.001 10.1016/j.mam.2012.05.011 10.1038/ng1262 10.1002/lary.21291 10.1155/2014/582849 10.1074/jbc.M305000200 10.1371/journal.pone.0036066 10.3109/00016486509124579 10.2217/epi.10.44 10.1073/pnas.262658999 10.1097/01.mlg.0000197630.85208.36 10.1111/j.1471-4159.2009.05871.x 10.1016/j.brainres.2008.03.031 10.1016/j.brainres.2007.08.090 10.1093/hmg/ddm088 10.1097/WNR.0b013e328350235f 10.1016/j.jneumeth.2008.02.022 10.1016/j.jnutbio.2009.12.009 10.3945/ajcn.110.005744 10.1007/BF00464266 10.1093/bioinformatics/19.2.185 10.1016/j.neuroscience.2009.07.059 10.1016/j.ijdevneu.2007.12.003 10.1016/j.heares.2007.07.002 10.1016/S0378-5955(98)00029-X 10.3109/00016489409126037 10.1038/ng1226 10.1038/ng.830 10.1007/BF00176533 10.1016/j.bcp.2011.07.093 10.1093/hmg/ddu002 10.1016/j.mam.2012.05.008 10.1101/lm.026575.112 10.1002/dneu.20746 10.3109/00016489609137935 10.1177/000348949110000809 10.1254/jphs.11227FP 10.1523/JNEUROSCI.1541-10.2010 10.1016/S0021-9258(17)36709-1 10.1073/pnas.0908786106 10.3109/00206090009073057 10.1055/s-0042-1748517 10.1016/j.biopsych.2004.11.046 10.1016/j.otohns.2010.08.031 10.1159/000106478 10.1093/ajcn/69.3.564 10.1080/00016480600702118 10.1242/dev.126.11.2335 10.7326/0003-4819-146-1-200701020-00003 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: HM. Performed the experiments: HM FM. Analyzed the data: HM FM. Contributed reagents/materials/analysis tools: HM FM MF TT TM. Wrote the paper: HM FM MF TT TM. Competing Interests: The authors have declared that no competing interests exist. |
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References | J Dufner-Beattie (ref14) 2007; 16 IM Quesada (ref15) 2011; 22 JF Willott (ref30) 1998; 119 J Jeong (ref12) 2013; 34 K Noben-Trauth (ref28) 2003; 35 GE Shambaugh Jr (ref4) 1989; 10 K Ochi (ref6) 1997; 100 J Dufner-Beattie (ref34) 2003; 278 D Reser (ref49) 1999; 20 RJ Marano (ref39) 2012; 24 GE Shambaugh Jr (ref3) 1985; 6 L Huang (ref13) 2013; 34 PG van Overveld (ref23) 2003; 35 JC King (ref11) 2011; 94 H Morsli (ref38) 1999; 126 H Mutai (ref44) 2009; 163 LJ Hoeve (ref47) 1990; 247 D Mikaelian (ref35) 1965; 59 J Waldhaus (ref22) 2012; 7 H Mutai (ref21) 2009; 69 S Nicholas (ref25) 1999; 10 KE Rarey (ref45) 1996; 116 M Gersdorff (ref8) 1987; 244 S Someya (ref48) 2007; 1182 MJ Provenzano (ref20) 2007; 233 H Hashimoto (ref18) 2010; 2 Y Fujinami (ref31) 2012; 118 BN Singh (ref53) 2011; 82 R Srividhya (ref54) 2008; 26 ref2 CH Yang (ref10) 2011; 121 I Ichimiya (ref46) 1994; 114 XR Zeng (ref43) 1994; 269 L Tremolizzo (ref36) 2002; 99 AO Lasisi (ref17) 2010; 143 Y Benjamini (ref33) 1995; 57 WS Kang (ref5) 2012; 23 JB Shin (ref29) 2010; 30 IB Zovkic (ref19) 2013; 20 J Durga (ref52) 2007; 146 BM Bolstad (ref32) 2003; 19 JP Pillion (ref26) 2000; 39 T Mikuriya (ref40) 2008; 1212 M D'Souza (ref42) 2008; 171 FQ Chen (ref50) 2009; 108 DK Houston (ref16) 1999; 69 E Van Eyken (ref1) 2007; 12 CJ Klein (ref24) 2011; 43 M Drottar (ref51) 2006; 116 G Berkiten (ref7) 2015; 36 L Tremolizzo (ref37) 2005; 57 FJ Kaiser (ref27) 2014; 23 S Someya (ref55) 2009; 106 PB Paaske (ref9) 1991; 100 MG De Silva (ref41) 2006; 126 |
References_xml | – volume: 36 start-page: 230 year: 2015 ident: ref7 article-title: Effects of serum zinc level on tinnitus publication-title: Am J Otolaryngol doi: 10.1016/j.amjoto.2014.11.001 contributor: fullname: G Berkiten – volume: 34 start-page: 612 year: 2013 ident: ref12 article-title: The SLC39 family of zinc transporters publication-title: Mol Aspects Med doi: 10.1016/j.mam.2012.05.011 contributor: fullname: J Jeong – volume: 35 start-page: 315 year: 2003 ident: ref23 article-title: Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy publication-title: Nat Genet doi: 10.1038/ng1262 contributor: fullname: PG van Overveld – volume: 121 start-page: 617 year: 2011 ident: ref10 article-title: Zinc in the treatment of idiopathic sudden sensorineural hearing loss publication-title: Laryngoscope doi: 10.1002/lary.21291 contributor: fullname: CH Yang – ident: ref2 doi: 10.1155/2014/582849 – volume: 278 start-page: 33474 year: 2003 ident: ref34 article-title: The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice publication-title: J Biol Chem doi: 10.1074/jbc.M305000200 contributor: fullname: J Dufner-Beattie – volume: 7 start-page: e36066 year: 2012 ident: ref22 article-title: Stemness of the organ of corti relates to the epigenetic status of sox2 enhancers publication-title: PLoS One doi: 10.1371/journal.pone.0036066 contributor: fullname: J Waldhaus – volume: 59 start-page: 451 year: 1965 ident: ref35 article-title: Development of hearing in the normal CBA-J mouse: Correlation of Physiological Observations with Behavioral Responses and with Cochlear Anatomy publication-title: Acta Oto-Laryngologica doi: 10.3109/00016486509124579 contributor: fullname: D Mikaelian – volume: 2 start-page: 657 year: 2010 ident: ref18 article-title: Molecular coupling of DNA methylation and histone methylation publication-title: Epigenomics doi: 10.2217/epi.10.44 contributor: fullname: H Hashimoto – volume: 99 start-page: 17095 year: 2002 ident: ref36 article-title: An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.262658999 contributor: fullname: L Tremolizzo – volume: 116 start-page: 292 year: 2006 ident: ref51 article-title: The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs publication-title: Laryngoscope doi: 10.1097/01.mlg.0000197630.85208.36 contributor: fullname: M Drottar – volume: 108 start-page: 1226 year: 2009 ident: ref50 article-title: Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea publication-title: J Neurochem doi: 10.1111/j.1471-4159.2009.05871.x contributor: fullname: FQ Chen – volume: 1212 start-page: 9 year: 2008 ident: ref40 article-title: Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone publication-title: Brain Res doi: 10.1016/j.brainres.2008.03.031 contributor: fullname: T Mikuriya – volume: 1182 start-page: 26 year: 2007 ident: ref48 article-title: Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice publication-title: Brain Res doi: 10.1016/j.brainres.2007.08.090 contributor: fullname: S Someya – volume: 16 start-page: 1391 year: 2007 ident: ref14 article-title: The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm088 contributor: fullname: J Dufner-Beattie – volume: 23 start-page: 201 year: 2012 ident: ref5 article-title: Effects of a zinc-deficient diet on hearing in CBA mice publication-title: Neuroreport doi: 10.1097/WNR.0b013e328350235f contributor: fullname: WS Kang – volume: 10 start-page: 156 year: 1989 ident: ref4 article-title: Zinc: the neglected nutrient publication-title: Am J Otol contributor: fullname: GE Shambaugh Jr – volume: 171 start-page: 279 year: 2008 ident: ref42 article-title: Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice publication-title: J Neurosci Methods doi: 10.1016/j.jneumeth.2008.02.022 contributor: fullname: M D'Souza – volume: 100 start-page: 915 year: 1997 ident: ref6 article-title: The serum zinc level in patients with tinnitus and the effect of zinc treatment publication-title: Otolaryngol Jpn contributor: fullname: K Ochi – volume: 22 start-page: 153 year: 2011 ident: ref15 article-title: Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2009.12.009 contributor: fullname: IM Quesada – volume: 94 start-page: 679S year: 2011 ident: ref11 article-title: Zinc: an essential but elusive nutrient publication-title: Am J Clin Nutr doi: 10.3945/ajcn.110.005744 contributor: fullname: JC King – volume: 244 start-page: 190 year: 1987 ident: ref8 article-title: A clinical correlation between hypozincemia and tinnitus publication-title: Arch Otorhinolaryngol doi: 10.1007/BF00464266 contributor: fullname: M Gersdorff – volume: 19 start-page: 185 year: 2003 ident: ref32 article-title: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias publication-title: Bioinformatics doi: 10.1093/bioinformatics/19.2.185 contributor: fullname: BM Bolstad – volume: 163 start-page: 1255 year: 2009 ident: ref44 article-title: Mitotic activity and specification of fibrocyte subtypes in the developing rat cochlear lateral wall publication-title: Neuroscience doi: 10.1016/j.neuroscience.2009.07.059 contributor: fullname: H Mutai – volume: 26 start-page: 217 year: 2008 ident: ref54 article-title: Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (-)-epigallocatechin-3-gallate publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2007.12.003 contributor: fullname: R Srividhya – volume: 233 start-page: 1 year: 2007 ident: ref20 article-title: A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns publication-title: Hear Res doi: 10.1016/j.heares.2007.07.002 contributor: fullname: MJ Provenzano – volume: 119 start-page: 27 year: 1998 ident: ref30 article-title: Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains publication-title: Hear Res doi: 10.1016/S0378-5955(98)00029-X contributor: fullname: JF Willott – volume: 114 start-page: 167 year: 1994 ident: ref46 article-title: Immunolocalization of Na+, K(+)-ATPase, Ca(++)-ATPase, calcium-binding proteins, and carbonic anhydrase in the guinea pig inner ear publication-title: Acta Otolaryngol doi: 10.3109/00016489409126037 contributor: fullname: I Ichimiya – volume: 35 start-page: 21 year: 2003 ident: ref28 article-title: Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss publication-title: Nat Genet doi: 10.1038/ng1226 contributor: fullname: K Noben-Trauth – volume: 43 start-page: 595 year: 2011 ident: ref24 article-title: Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss publication-title: Nat Genet doi: 10.1038/ng.830 contributor: fullname: CJ Klein – volume: 247 start-page: 267 year: 1990 ident: ref47 article-title: Hearing loss related to zinc deficiency in rats publication-title: Eur Arch Otorhinolaryngol doi: 10.1007/BF00176533 contributor: fullname: LJ Hoeve – volume: 82 start-page: 1807 year: 2011 ident: ref53 article-title: Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2011.07.093 contributor: fullname: BN Singh – volume: 23 start-page: 2888 year: 2014 ident: ref27 article-title: Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance publication-title: Hum Mol Genet doi: 10.1093/hmg/ddu002 contributor: fullname: FJ Kaiser – volume: 34 start-page: 548 year: 2013 ident: ref13 article-title: The SLC30 family of zinc transporters—a review of current understanding of their biological and pathophysiological roles publication-title: Mol Aspects Med doi: 10.1016/j.mam.2012.05.008 contributor: fullname: L Huang – volume: 20 start-page: 61 year: 2013 ident: ref19 article-title: Epigenetic regulation of memory formation and maintenance publication-title: Learn Mem doi: 10.1101/lm.026575.112 contributor: fullname: IB Zovkic – volume: 20 start-page: 731 year: 1999 ident: ref49 article-title: l- and d-methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity publication-title: Neurotoxicology contributor: fullname: D Reser – volume: 69 start-page: 913 year: 2009 ident: ref21 article-title: Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium publication-title: Dev Neurobiol doi: 10.1002/dneu.20746 contributor: fullname: H Mutai – volume: 116 start-page: 833 year: 1996 ident: ref45 article-title: Localization of Cu/Zn-SOD and Mn-SOD in the rat cochlea publication-title: Acta Otolaryngol doi: 10.3109/00016489609137935 contributor: fullname: KE Rarey – volume: 100 start-page: 647 year: 1991 ident: ref9 article-title: Zinc in the management of tinnitus. Placebo-controlled trial publication-title: Ann Otol Rhinol Laryngol doi: 10.1177/000348949110000809 contributor: fullname: PB Paaske – volume: 118 start-page: 363 year: 2012 ident: ref31 article-title: A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea publication-title: J Pharmacol Sci doi: 10.1254/jphs.11227FP contributor: fullname: Y Fujinami – volume: 30 start-page: 9683 year: 2010 ident: ref29 article-title: The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1541-10.2010 contributor: fullname: JB Shin – volume: 269 start-page: 13748 year: 1994 ident: ref43 article-title: DNA polymerase delta is involved in the cellular response to UV damage in human cells publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)36709-1 contributor: fullname: XR Zeng – volume: 106 start-page: 19432 year: 2009 ident: ref55 article-title: Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0908786106 contributor: fullname: S Someya – volume: 39 start-page: 80 year: 2000 ident: ref26 article-title: Auditory brainstem responses in Rett syndrome: effects of hyperventilation, seizures, and tympanometric variables publication-title: Audiology doi: 10.3109/00206090009073057 contributor: fullname: JP Pillion – volume: 10 start-page: 436 year: 1999 ident: ref25 article-title: Otoacoustic emission findings in Rett syndrome publication-title: J Am Acad Audiol doi: 10.1055/s-0042-1748517 contributor: fullname: S Nicholas – volume: 57 start-page: 500 year: 2005 ident: ref37 article-title: Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.11.046 contributor: fullname: L Tremolizzo – volume: 143 start-page: 826 year: 2010 ident: ref17 article-title: Age-related hearing loss, vitamin B12, and folate in the elderly publication-title: Otolaryngol Head Neck Surg doi: 10.1016/j.otohns.2010.08.031 contributor: fullname: AO Lasisi – volume: 12 start-page: 345 year: 2007 ident: ref1 article-title: The complexity of age-related hearing impairment: contributing environmental and genetic factors publication-title: Audiol Neurootol doi: 10.1159/000106478 contributor: fullname: E Van Eyken – volume: 6 start-page: 116 year: 1985 ident: ref3 article-title: Zinc and presbycusis publication-title: Am J Otol contributor: fullname: GE Shambaugh Jr – volume: 69 start-page: 564 year: 1999 ident: ref16 article-title: Age-related hearing loss, vitamin B-12, and folate in elderly women publication-title: Am J Clin Nutr doi: 10.1093/ajcn/69.3.564 contributor: fullname: DK Houston – volume: 57 start-page: 289 year: 1995 ident: ref33 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J Roy Statist Soc Ser B contributor: fullname: Y Benjamini – volume: 126 start-page: 1148 year: 2006 ident: ref41 article-title: Gene expression changes during step-wise differentiation of embryonic stem cells along the inner ear hair cell pathway publication-title: Acta Otolaryngol doi: 10.1080/00016480600702118 contributor: fullname: MG De Silva – volume: 126 start-page: 2335 year: 1999 ident: ref38 article-title: Otx1 and Otx2 activities are required for the normal development of the mouse inner ear publication-title: Development doi: 10.1242/dev.126.11.2335 contributor: fullname: H Morsli – volume: 24 start-page: 603 year: 2012 ident: ref39 article-title: Age related changes in gene expression within the cochlea of C57BL/6J mice publication-title: Aging Clin Exp Res contributor: fullname: RJ Marano – volume: 146 start-page: 1 year: 2007 ident: ref52 article-title: Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-1-200701020-00003 contributor: fullname: J Durga |
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Snippet | Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory... |
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SubjectTerms | Acids Age Analysis Animals Attenuation Auditory system Brain research Brain stem Catechin - analogs & derivatives Catechin - pharmacology Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cochlea Cochlea - drug effects Cochlea - metabolism Cyanocobalamin Deoxyribonucleic acid DNA DNA methylation DNA methyltransferase DNA microarrays DNA probes Down-Regulation - drug effects Environmental factors Epigenesis, Genetic Epigenetic inheritance Epigenetics Epithelium Evoked Potentials, Auditory, Brain Stem - drug effects Folic acid Gene expression Hearing loss Hearing Loss - chemically induced Hearing Loss - metabolism Hearing Loss - pathology Hearing protection Histone deacetylase Immunohistochemistry Investigations Laboratories Medical research Methionine Methionine - toxicity Mice Mice, Inbred DBA Microscopy, Fluorescence Oligonucleotide Array Sequence Analysis Organ of Corti Organ of Corti - metabolism Polymerase chain reaction Proteins Reagents Real-Time Polymerase Chain Reaction Serum levels Spiral ganglion Spiral Ganglion - metabolism Stem cells Transferases Up-regulation Up-Regulation - drug effects Valproic acid Valproic Acid - toxicity Vitamin B12 Zinc |
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Title | Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4 |
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