Ketogenic diet improves core symptoms of autism in BTBR mice

• Published in: PloS one Vol. 8; no. 6; p. e65021
• Main Authors: Ruskin, David N, Svedova, Julia, Cote, Jessica L, Sandau, Ursula, Rho, Jong M, Kawamura, Jr, Masahito, Boison, Detlev, Masino, Susan A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.06.2013; Public Library of Science (PLoS)
• Subjects: Adenosine; Animal cognition; Animals; Autism; Autistic Disorder - diet therapy; Behavior; Benzazepines; Biology; Brain research; Brain Waves; CA3 Region, Hippocampal - physiopathology; Carbohydrates; Cerebral Cortex - physiopathology; Communication; Convulsions & seizures; Cornea; Diet; Diet, Ketogenic; Disorders; EEG; Epilepsy; Flurothyl; Food preferences; High fat diet; House mouse; Humans; Ketogenesis; Laboratory animals; Low carbohydrate diet; Male; Medicine; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Nervous system diseases; Neurobiology; Neurological diseases; Neurosciences; Pentylenetetrazole; Seizing; Seizures; Seizures (Medicine); Seizures - chemically induced; Seizures - diet therapy; Social behavior; Oregon; United States > US; Connecticut

Autism spectrum disorders share three core symptoms: impaired sociability, repetitive behaviors and communication deficits. Incidence is rising, and current treatments are inadequate. Seizures are a common comorbidity, and since the 1920's a high-fat, low-carbohydrate ketogenic diet has been us...