Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans

• Published in: PloS one Vol. 11; no. 1; p. e0146087
• Main Authors: Basaran, Kemal Erdem, Villongco, Michael, Ho, Baran, Ellis, Erika, Zarndt, Rachel, Antonova, Julie, Hopkins, Susan R., Powell, Frank L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.01.2016; Public Library of Science (PLoS)
• Subjects: Acclimatization; Acclimatization - drug effects; Adolescent; Adult; Altitude; Altitude effects; Animal models; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Brain stem; Breathing; Carotid body; Carotid Body - drug effects; Carotid Body - physiopathology; Chemoreceptor Cells - drug effects; Chemoreceptors; Chemoreceptors (internal); Chronic Disease; Cross-Over Studies; Dosage and administration; Double-Blind Method; Female; Gene expression; High altitude; High-altitude environments; Humans; Hypoventilation; Hypoxemia; Hypoxia; Hypoxia (Aquatic ecology); Hypoxia - physiopathology; Ibuprofen; Ibuprofen - adverse effects; Ibuprofen - pharmacology; Inflammation; Lung diseases; Male; Measurement methods; Medicine; Neural plasticity; Neuronal Plasticity - drug effects; Neuroplasticity; Nonsteroidal anti-inflammatory drugs; Oxygen - blood; Pain; Partial Pressure; Physiology; Respiration - drug effects; Respiratory Center - drug effects; Respiratory Center - physiopathology; Rodents; Sea level; Signaling; Ventilation; Ventilatory behavior; Young Adult

Ventilatory acclimatization to hypoxia is a time-dependent increase in ventilation and the hypoxic ventilatory response (HVR) that involves neural plasticity in both carotid body chemoreceptors and brainstem respiratory centers. The mechanisms of such plasticity are not completely understood but rec...