Evaluation of Approaches to Monitor Staphylococcus aureus Virulence Factor Expression during Human Disease

• Published in: PloS one Vol. 10; no. 2; p. e0116945
• Main Authors: Rozemeijer, Wouter, Fink, Pamela, Rojas, Eduardo, Jones, C. Hal, Pavliakova, Danka, Giardina, Peter, Murphy, Ellen, Liberator, Paul, Jiang, Qin, Girgenti, Douglas, Peters, Remco P. H., Savelkoul, Paul H. M., Jansen, Kathrin U., Anderson, Annaliesa S., Kluytmans, Jan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.02.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Antigens; Bacterial Capsules - immunology; Capsular polysaccharides; Coagulase - genetics; Coagulase - immunology; Coagulase - metabolism; Drug resistance; Female; Gene expression; Genetic research; Health aspects; Human behavior; Humans; Immune response; Immunoassay; Immunoglobulins; Immunology; Infection; Infections; Male; Manganese; Middle Aged; Nasal Mucosa - microbiology; Pathogens; Patients; Polysaccharides; Proteins; R&D; Research & development; Ribonucleic acid; RNA; Serogroup; Serology; Staphylococcal Infections - microbiology; Staphylococcal Vaccines - immunology; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - immunology; Staphylococcus aureus - pathogenicity; Staphylococcus aureus infections; Staphylococcus infections; Transcription; Triose-phosphate isomerase; Vaccines; Virulence; Virulence (Microbiology); Virulence factors; Virulence Factors - genetics; Virulence Factors - immunology; Virulence Factors - metabolism; New York; Netherlands; Pearl River; United States > US

Staphylococcus aureus is a versatile pathogen of medical significance, using multiple virulence factors to cause disease. A prophylactic S. aureus 4-antigen (SA4Ag) vaccine comprising capsular polysaccharide (types 5 and 8) conjugates, clumping factor A (ClfA) and manganese transporter C (MntC) is u...