Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion - Chang, Douglas C.; Piaggi, Paolo; Hanson, Robert L.; Knowler, William C.; Bucci, John; Thio, Guene; Hohenadel, Maximilian G.; Bogardus, Clifton; Krakoff, Jonathan (PloS one, 2015)
Keywords: Adaptive systems; Adolescent; Adult; Analysis; Antibodies; Antigens; Autoantibodies; Autoantibodies - immunology; Autoantigens; Autoimmune diseases; Bioindicators; Biomarkers; Cohort Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - metabolism; Drb1 protein; Drug development; Epidemiology; Female; Glucose; Glucose tolerance; Haplotypes; Histocompatibility antigen HLA; HLA antigens; HLA Antigens - genetics; HLA Antigens - metabolism; Humans; Immune system; Immunoglobulins; Immunological tolerance; Insulin; Insulin - metabolism; Insulin Secretion; Kidney diseases; Male; Metabolism; Middle Aged; Obesity; Pathogenesis; Polypeptides; PPAR gamma - metabolism; Protein Array Analysis; Protein arrays; Proteins; Sensitivity and Specificity; Type 2 diabetes; Ubiquitin-Conjugating Enzymes - metabolism; Young Adult; United States; United States--US; Arizona; California