Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

• Published in: PloS one Vol. 13; no. 2; p. e0193175
• Main Authors: Huang, Yu-hua, Chen, Chiung-Mei, Lee, Yun-Shien, Chang, Kuo-Hsuan, Chen, Huei-Wen, Chen, Yi-Chun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.02.2018; Public Library of Science (PLoS)
• Subjects: Biology and life sciences; Body mass; Body mass index; Body size; Brain research; Breast cancer; Cardiovascular disease; Cerebral infarction; Cholesterol; Coronary artery; Coronary artery disease; Coronary vessels; Deoxyribonucleic acid; Development and progression; DNA; DNA sequencing; Gene sequencing; Genetic aspects; Health risks; Heart diseases; Hospitals; Infarction; Ischemia; Leukocytes; Medical imaging; Medical research; Medicine; Medicine and Health Sciences; Mitochondria; Mitochondrial DNA; Mutagenesis; Mutation; Neurology; Patients; Physiological aspects; Polymerase chain reaction; Research and Analysis Methods; Risk factors; Stroke; Studies; White blood cells; Taiwan

Coronary artery disease is associated with a common mitochondrial DNA alteration, a 4977 bp deletion (mtDNA4977). The role of mtDNA4977 in ischemic stroke is unknown. Real-time quantitative PCR was performed to quantify total mtDNA and mtDNA4977 in leukocytes in 283 ischemic stroke cases and 135 con...