Analysis of domain-swapped oligomers reveals local sequence preferences and structural imprints at the linker regions and swapped interfaces

• Published in: PloS one Vol. 7; no. 7; p. e39305
• Main Authors: Shingate, Prashant, Sowdhamini, R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.07.2012; Public Library of Science (PLoS)
• Subjects: Algorithms; Alzheimer's disease; Amino acid sequence; Analysis; Bioinformatics; Biology; Databases, Protein; Encephalopathy; Homology; Interfaces; Mutation; Nervous system diseases; Neurodegenerative diseases; Neurological diseases; Oligomerization; Oligomers; Predictions; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Proteins; Proteins - chemistry; Proteins - genetics; Residues; Sequence Analysis, Protein; Spongiform encephalopathy; Structural members

3D domain swapping is an oligomerization process in which structural elements get exchanged between subunits. This mechanism grasped interest of many researchers due to its association with neurodegenerative diseases like Alzheimer's disease, spongiform encephalopathy etc. Despite the biomedica...