Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study

• Published in: PloS one Vol. 10; no. 8; p. e0136560
• Main Authors: Fernández-Palomeque, Carlos, Grau, Andres, Perelló, Joan, Sanchis, Pilar, Isern, Bernat, Prieto, Rafel M., Costa-Bauzá, Antonia, Caldés, Onofre J., Bonnin, Oriol, Garcia-Raja, Ana, Bethencourt, Armando, Grases, Felix
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.08.2015; Public Library of Science (PLoS)
• Subjects: Aged; Aging; Annuli; Atherosclerosis; Blood; Blood levels; Calcification; Calcification (ectopic); Calcification (Physiology); Calcification, Physiologic; Calcinosis - blood; Calcinosis - urine; Calcium; Calcium (blood); Calcium phosphates; Cardiomyopathies - blood; Cardiomyopathies - epidemiology; Cardiomyopathies - urine; Cardiovascular disease; Cardiovascular diseases; Coronary vessels; Cross-Sectional Studies; Crystallization; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus - epidemiology; Durapatite - metabolism; Echocardiography; Excretion; Female; Food consumption; Geriatrics; Health risks; Health sciences; Heart; Heart Valve Diseases - blood; Heart Valve Diseases - epidemiology; Heart Valve Diseases - urine; Heart Valves - pathology; Humans; Hydroxyapatite; Hydroxyapatites; Hypercholesterolemia; Hypercholesterolemia - epidemiology; Hypertension; Kidney diseases; Laboratories; Leukocyte Count; Leukocytes; Male; Mitral Valve - pathology; Multivariate analysis; Older people; Phosphates - blood; Physiological aspects; Phytic Acid - urine; Population; Population studies; R&D; Research & development; Risk analysis; Risk Factors; Soft tissues; Supersaturation; Urine; White blood cells; Spain; Majorca; Balearic Islands

Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of car...