Frailty in Old Age Is Associated with Decreased Interleukin-12/23 Production in Response to Toll-Like Receptor Ligation

• Published in: PloS one Vol. 8; no. 6; p. e65325
• Main Authors: Compté, Nathalie, Zouaoui Boudjeltia, Karim, Vanhaeverbeek, Michel, De Breucker, Sandra, Tassignon, Joel, Trelcat, Anne, Pepersack, Thierry, Goriely, Stanislas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.06.2013; Public Library of Science (PLoS)
• Subjects: Activities of daily living; Adult; Age; Aged; Aged, 80 and over; Aging; Analysis; Bacteria; Blood & organ donations; Cells, Cultured; Chronic diseases; Chronic illnesses; Comorbidity; Cytokines; Cytomegalovirus; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Disease susceptibility; Family medical history; Female; Frail Elderly; Frailty; Geriatrics; Health aspects; Health care; Hematology; Heterogeneity; Hospitals; Humans; Imidazoles - pharmacology; Immune response; Immune system; Immunity, Innate; Immunology; Infections; Influenza; Innate immunity; Intercellular Adhesion Molecule-1 - metabolism; Interleukin 12; Interleukin 23; Interleukin-12 - biosynthesis; Interleukin-23 - biosynthesis; Interleukins; Laboratories; Ligands; Lipopolysaccharides - pharmacology; Male; Medicine; Middle Aged; Monocytes; Nosocomial infections; Nutritional status; Nutritional Status - immunology; Older people; Patients; Production management; Proteins; Recruitment; Regression analysis; Rodents; Serology; Signal Transduction; Signaling; Telomeres; TLR4 protein; TLR7 protein; Toll-like receptors; Toll-Like Receptors - agonists; Toll-Like Receptors - metabolism; Type 2 diabetes; Vaccines; Viral infections; Womens health; Young Adult; Belgium

Aging is associated with progressive alterations of immune functions, leading to higher susceptibility to bacterial and viral infections and reduced vaccine responses. Data concerning cytokine production in response to Toll-like receptor (TLR) ligands are highly variable in old people, reflecting th...