Frailty in Old Age Is Associated with Decreased Interleukin-12/23 Production in Response to Toll-Like Receptor Ligation - Compté, Nathalie; Zouaoui Boudjeltia, Karim; Vanhaeverbeek, Michel; De Breucker, Sandra; Tassignon, Joel; Trelcat, Anne; Pepersack, Thierry; Goriely, Stanislas (PloS one, 2013)
Keywords: Activities of daily living; Adult; Age; Aged; Aged, 80 and over; Aging; Analysis; Bacteria; Blood & organ donations; Cells, Cultured; Chronic diseases; Chronic illnesses; Comorbidity; Cytokines; Cytomegalovirus; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Disease susceptibility; Family medical history; Female; Frail Elderly; Frailty; Geriatrics; Health aspects; Health care; Hematology; Heterogeneity; Hospitals; Humans; Imidazoles - pharmacology; Immune response; Immune system; Immunity, Innate; Immunology; Infections; Influenza; Innate immunity; Intercellular Adhesion Molecule-1 - metabolism; Interleukin 12; Interleukin 23; Interleukin-12 - biosynthesis; Interleukin-23 - biosynthesis; Interleukins; Laboratories; Ligands; Lipopolysaccharides - pharmacology; Male; Medicine; Middle Aged; Monocytes; Nosocomial infections; Nutritional status; Nutritional Status - immunology; Older people; Patients; Production management; Proteins; Recruitment; Regression analysis; Rodents; Serology; Signal Transduction; Signaling; Telomeres; TLR4 protein; TLR7 protein; Toll-like receptors; Toll-Like Receptors - agonists; Toll-Like Receptors - metabolism; Type 2 diabetes; Vaccines; Viral infections; Womens health; Young Adult; Belgium