Reciprocal regulation of development of neutrophil-dendritic cell hybrids in mice by IL-4 and interferon-gamma

• Published in: PloS one Vol. 8; no. 11; p. e82929
• Main Authors: Geng, Shuo, Matsushima, Hironori, Okamoto, Takashi, Yao, Yi, Lu, Ran, Takashima, Akira
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2013; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Analysis; Animals; Antigen-presenting cells; Antigens; Automation; B cells; Bacterial infections; Bone marrow; CD11c antigen; Cell culture; Cell hybrids; Cell Separation; Chemokines; Cytokines; Dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - immunology; E coli; Flow Cytometry; Granulocyte-macrophage colony-stimulating factor; Growth factors; Hybrids; Immune response; Immunity; Immunologic factors; Immunology; In vivo methods and tests; Inflammation; Interferon; Interferon-gamma - pharmacology; Interleukin 4; Interleukin-4 - pharmacology; Lesions; Leukocytes (neutrophilic); Ligands; Lymphocytes; Major histocompatibility complex; Medicine; Mice; Mice, Inbred C57BL; Neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Peritonitis; Phagocytes; Surface markers; γ-Interferon; United States > US; Ohio

Neutrophils contribute to innate host immunity by functioning as professional phagocytes, whereas dendritic cells (DCs) are prototypic antigen presenting cells (APCs) responsible for the induction of adaptive immune responses. We have demonstrated recently that neutrophils trans-differentiate into a...